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All Profiles

Dr Akusa Patrice Mawa

Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2020-11-01
End Date 2023-10-31
Project Code TMA2019CDF-2708
Status Active

Title

Exploring immune responses in primary and more advanced Schistosoma mansoni infection and treatment of preschool-age children using Aurora spectral flow cytometry

Host Organisation

Institution Country
Uganda National Health Research Organisation (UNHRO) Uganda

Current Organisation

Uganda Virus Research Institute

Current Job Title

Principal Research Officer

Education

Institution Degree Year
London School of Hygiene & Tropical Medicine, United Kingdom PhD
London School of Hygiene & Tropical Medicine, United Kingdom MSc 2008-09-30

Areas Of Specialisation

Neglected Infectious Diseases (NID)

Grants

Establishing a pool of school-going adolescent boys and girls as vaccination Ambassadors in Entebbe, Uganda
Grant Code:
Source of funding:
IMPRINT
Amount:
12500
Role:
Principal Investigator
Start Date:
2020-01-01
End Date:
2021-01-01
Exploring B cell and antibody responses in preschool-age children to inform development of vaccines and immunotherapy against schistosomiasis
Grant Code:
Source of funding:
MRC Uganda
Amount:
30000
Role:
Principal Investigator
Start Date:
2020-01-01
End Date:
2022-01-01
Tropical Medicine Research Center: Uganda Schistosomiasis Multidisciplinary Research Center. Principal Investigator
Grant Code:
U01AI168609.
Source of funding:
NIH
Amount:
2653173
Role:
Co-investigator
Start Date:
2022-01-01
End Date:
2027-01-01

Publications

Factors associated with tuberculosis infection, and with anti-mycobacterial immune responses, among five year olds BCG-immunised at birth in Entebbe, Uganda.
Authors:
Lule SA , author
Mawa PA , author
Nkurunungi G , author
Nampijja M , author
Kizito D , author
Akello F , author
Muhangi L , author
Elliott AM , author
Webb EL , author
Date:
2015-02-01
Journal:
Content:
Identifiers:
PMID: 25529292
PMC: PMC4317190
DOI: 10.1016/j.vaccine.2014.12.015
Effect of maternal Schistosoma mansoni infection and praziquantel treatment during pregnancy on Schistosoma mansoni infection and immune responsiveness among offspring at age five years.
Authors:
Tweyongyere R , author
Naniima P , author
Mawa PA , author
Jones FM , author
Webb EL , author
Cose S , author
Dunne DW , author
Elliott AM , author
Date:
2013-01-01
Journal:
Content:
Identifiers:
PMID: 24147175
PMC: PMC3798616
DOI: 10.1371/journal.pntd.0002501
Effects of maternal and infant co-infections, and of maternal immunisation, on the infant response to BCG and tetanus immunisation.
Authors:
Elliott AM , author
Mawa PA , author
Webb EL , author
Nampijja M , author
Lyadda N , author
Bukusuba J , author
Kizza M , author
Namujju PB , author
Nabulime J , author
Ndibazza J , author
Muwanga M , author
Whitworth JA , author
Date:
2010-12-01
Journal:
Content:
Identifiers:
PMID: 21040693
PMC: PMC3021124
DOI: 10.1016/j.vaccine.2010.10.047
The influence of BCG vaccine strain on mycobacteria-specific and non-specific immune responses in a prospective cohort of infants in Uganda.
Authors:
Anderson EJ , author
Webb EL , author
Mawa PA , author
Kizza M , author
Lyadda N , author
Nampijja M , author
Elliott AM , author
Date:
2012-03-01
Journal:
Content:
Identifiers:
PMID: 22300718
PMC: PMC3314967
DOI: 10.1016/j.vaccine.2012.01.053
Effect of praziquantel treatment during pregnancy on cytokine responses to schistosome antigens: results of a randomized, placebo-controlled trial.
Authors:
Tweyongyere R , author
Mawa PA , author
Ngom-Wegi S , author
Ndibazza J , author
Duong T , author
Vennervald BJ , author
Dunne DW , author
Katunguka-Rwakishaya E , author
Elliott AM , author
Date:
2008-12-01
Journal:
Content:
Identifiers:
PMID: 18983246
PMC: PMC2892302
DOI: 10.1086/593215
Helminths and HIV infection: epidemiological observations on immunological hypotheses.
Authors:
Brown M , author
Mawa PA , author
Kaleebu P , author
Elliott AM , author
Date:
2006-11-01
Journal:
Content:
Identifiers:
PMID: 17042933
PMC: PMC1636684
DOI: 10.1111/j.1365-3024.2006.00904.x
Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on immune responses to schistosome antigens among the offspring: results of a randomised, placebo-controlled trial.
Authors:
Tweyongyere R , author
Mawa PA , author
Kihembo M , author
Jones FM , author
Webb EL , author
Cose S , author
Dunne DW , author
Vennervald BJ , author
Elliott AM , author
Date:
2011-01-01
Journal:
Content:
Identifiers:
PMID: 21888656
PMC: PMC3176493
DOI: 10.1186/1471-2334-11-234
The impact of maternal infection with Mycobacterium tuberculosis on the infant response to bacille Calmette-Guerin immunization.
Authors:
Mawa PA , author
Nkurunungi G , author
Egesa M , author
Webb EL , author
Smith SG , author
Kizindo R , author
Akello M , author
Lule SA , author
Muwanga M , author
Dockrell HM , author
Cose S , author
Elliott AM , author
Date:
2015-06-01
Journal:
Content:
Identifiers:
PMID: 25964450
PMC: PMC4527383
DOI: 10.1098/rstb.2014.0137
Associations between helminth infection and CD4+ T cell count, viral load and cytokine responses in HIV-1-infected Ugandan adults.
Authors:
Elliott AM , author
Mawa PA , author
Joseph S , author
Namujju PB , author
Kizza M , author
Nakiyingi JS , author
Watera C , author
Dunne DW , author
Whitworth JA , author
Date:
2003-01-01
Journal:
Content:
Identifiers:
PMID: 12886815
DOI: 10.1016/S0035-9203(03)90040-X
Maternal BCG scar is associated with increased infant proinflammatory immune responses.
Authors:
Mawa PA , author
Webb EL , author
Filali-Mouhim A , author
Nkurunungi G , author
Sekaly RP , author
Lule SA , author
Prentice S , author
Nash S , author
Dockrell HM , author
Elliott AM , author
Cose S , author
Date:
2016-11-01
Journal:
Content:
Identifiers:
PMID: 27914741
DOI: 10.1016/j.vaccine.2016.11.079
Impact of anthelminthic treatment in pregnancy and childhood on immunisations, infections and eczema in childhood: a randomised controlled trial.
Authors:
Ndibazza J , author
Mpairwe H , author
Webb EL , author
Mawa PA , author
Nampijja M , author
Muhangi L , author
Kihembo M , author
Lule SA , author
Rutebarika D , author
Apule B , author
Akello F , author
Akurut H , author
Oduru G , author
Naniima P , author
Kizito D , author
Kizza M , author
Kizindo R , author
Tweyongere R , author
Alcock KJ , author
Muwanga M , author
Date:
2012-01-01
Journal:
Content:
Identifiers:
PMID: 23236367
PMC: PMC3517620
DOI: 10.1371/journal.pone.0050325
Treatment of Schistosoma mansoni infection increases helminth-specific type 2 cytokine responses and HIV-1 loads in coinfected Ugandan adults.
Authors:
Brown M , author
Mawa PA , author
Joseph S , author
Bukusuba J , author
Watera C , author
Whitworth JA , author
Dunne DW , author
Elliott AM , author
Date:
2005-05-01
Journal:
Content:
Identifiers:
PMID: 15838791
DOI: 10.1086/429668
Effect of praziquantel treatment of Schistosoma mansoni during pregnancy on intensity of infection and antibody responses to schistosome antigens: results of a randomised, placebo-controlled trial.
Authors:
Tweyongyere R , author
Mawa PA , author
Emojong NO , author
Mpairwe H , author
Jones FM , author
Duong T , author
Dunne DW , author
Vennervald BJ , author
Katunguka-Rwakishaya E , author
Elliott AM , author
Date:
2009-01-01
Journal:
Content:
Identifiers:
PMID: 19296834
PMC: PMC2666740
DOI: 10.1186/1471-2334-9-32
Treatment with anthelminthics during pregnancy: what gains and what risks for the mother and child?
Authors:
Elliott AM , author
Ndibazza J , author
Mpairwe H , author
Muhangi L , author
Webb EL , author
Kizito D , author
Mawa P , author
Tweyongyere R , author
Muwanga M , author
Entebbe Mother and Baby Study Team , author
Date:
2011-10-01
Journal:
Content:
Identifiers:
PMID: 21810307
PMC: PMC3178871
DOI: 10.1017/S0031182011001053
The effect of tuberculin skin testing on viral load and anti-mycobacterial immune responses in HIV-1-infected Ugandan adults.
Authors:
Mawa PA , author
Pickering JM , author
Miiro G , author
Namujju PB , author
Watera C , author
Anyaegani G , author
Whitworth JA , author
Elliott AM , author
Date:
2004-05-01
Journal:
Content:
Identifiers:
PMID: 15137535
A randomised controlled trial of the effects of albendazole in pregnancy on maternal responses to mycobacterial antigens and infant responses to Bacille Calmette-Guerin (BCG) immunisation [ISRCTN32849447].
Authors:
Elliott AM , author
Namujju PB , author
Mawa PA , author
Quigley MA , author
Nampijja M , author
Nkurunziza PM , author
Belisle JT , author
Muwanga M , author
Whitworth JA , author
Mother and Baby study team , author
Date:
2005-01-01
Journal:
Content:
Identifiers:
PMID: 16371154
PMC: PMC1352364
DOI: 10.1186/1471-2334-5-115
Impairment of the Schistosoma mansoni-specific immune responses elicited by treatment with praziquantel in Ugandans with HIV-1 coinfection.
Authors:
Joseph S , author
Jones FM , author
Laidlaw ME , author
Mohamed G , author
Mawa PA , author
Namujju PB , author
Kizza M , author
Watera C , author
Whitworth JA , author
Dunne DW , author
Elliott AM , author
Date:
2004-08-01
Journal:
Content:
Identifiers:
PMID: 15243939
DOI: 10.1086/422396
Effect of single-dose anthelmintic treatment during pregnancy on an infant's response to immunisation and on susceptibility to infectious diseases in infancy: a randomised, double-blind, placebo-controlled trial.
Authors:
Webb EL , author
Mawa PA , author
Ndibazza J , author
Kizito D , author
Namatovu A , author
Kyosiimire-Lugemwa J , author
Nanteza B , author
Nampijja M , author
Muhangi L , author
Woodburn PW , author
Akurut H , author
Mpairwe H , author
Akello M , author
Lyadda N , author
Bukusuba J , author
Kihembo M , author
Kizza M , author
Kizindo R , author
Nabulime J , author
Ameke C , author
Date:
2011-01-01
Journal:
Content:
Identifiers:
PMID: 21176950
PMC: PMC3018567
DOI: 10.1016/S0140-6736(10)61457-2
The effect of tuberculin skin testing on viral load and anti-mycobacterial immune responses in HIV-1-infected Ugandan adults
Authors:
Mawa, P.A.
Pickering, J.M.
Miiro, G.
Namujju, P.B.
Watera, C.
Anyaegani, G.
Whitworth, J.A.G.
Elliott, A.M.
Date:
2004-01-01
Journal:
International Journal of Tuberculosis and Lung Disease
Content:
Identifiers:
EID: 2-s2.0-2442460014

Projects

Exploring immune responses in primary and more advanced Schistosoma mansoni infection and treatment
Fellow:
Akusa Patrice Mawa
Collaborators:
Name Country Institution
University of Cambridge Uganda Uganda National Health Research Organisation
Objectives:
1. To characterize immune responses of PSAC in primary and more advanced S. mansoni infection 2. To determine the effect of PZQ treatment of S. mansoni on immune responses in PSAC
Sites:
Albertine region in Uganda (Hoima and Buliisa districts)
Study Design:
Longitudinal cohort study
Subjects:
Preschool-age children
Outcomes:
1. Immune responses to S. mansoni infection of PSAC as measured by cytokine responses and immune cell frequencies 2. Effect of PZQ treatment of S. mansoni on immune responses in PSAC assessed using cytokine/chemokine responses and frequencies of immune cells
Start Date:
2021-11-01
End Date:
2023-10-31
Exploring immune responses in primary and more advanced Schistosoma mansoni infection and treatment
Fellow:
Akusa Patrice Mawa
Collaborators:
Name Country Institution
Preschool-age children Uganda Uganda National Health Research Organisation
Objectives:
1. To characterize immune responses of PSAC in primary and more advanced S. mansoni infection 2. To determine the effect of PZQ treatment of S. mansoni on immune responses in PSAC
Sites:
Albertine region in Uganda (Hoima and Buliisa districts)
Study Design:
Longitudinal cohort study
Subjects:
Preschool-age children
Outcomes:
1. Immune responses to S. mansoni infection of PSAC as measured by cytokine responses and immune cell frequencies 2. Effect of PZQ treatment of S. mansoni on immune responses in PSAC assessed using cytokine/chemokine responses and frequencies of immune cells
Start Date:
2021-11-01
End Date:
2023-10-31
Exploring immune responses in primary and more advanced Schistosoma mansoni infection and treatment
Fellow:
Akusa Patrice Mawa
Collaborators:
Name Country Institution
Preschool-age children Uganda Uganda National Health Research Organisation
Objectives:
1. To characterize immune responses of PSAC in primary and more advanced S. mansoni infection 2. To determine the effect of PZQ treatment of S. mansoni on immune responses in PSAC
Sites:
Albertine region in Uganda (Hoima and Buliisa districts)
Study Design:
Longitudinal cohort study
Subjects:
Preschool-age children
Outcomes:
1. Immune responses to S. mansoni infection of PSAC as measured by cytokine responses and immune cell frequencies 2. Effect of PZQ treatment of S. mansoni on immune responses in PSAC assessed using cytokine/chemokine responses and frequencies of immune cells
Start Date:
2021-11-01
End Date:
2023-10-31

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