EDCTP Alumni Network

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All Profiles

Dr Catherine Riou

Call Senior Fellowship (SF)
Programme EDCTP2
Start Date 2019-04-01
End Date 2024-03-31
Project Code TMA2017SF-1951
Status Active

Title

Deciphering the immunological signatures of the TB spectrum from infection to disease (TB-SPEC)

Host Organisation

Institution Country
South Africa

Current Organisation

University of Cape Town

Current Job Title

Chief Research Officer

Students Supervised

Type Name Title University Start Date End Date
Post-Doc Hygon Mutavhatsindi PhD University of Cape Town 2020 2022

Memberships

Role Committee/board Start Date End Date

Education

Institution Degree Year
University of Lyon, France PhD

Areas Of Specialisation

Tuberculosis (TB) HIV Flow cytometry T cell responses T cell polarization SARS-CoV-2

Grants

Adaptive responses to SARS-CoV-2 variants in the context of hybrid immunity and immune impairment
Grant Code:
226137/Z/22/Z
Source of funding:
Wellcome Trust
Amount:
600000
Role:
Researcher
Start Date:
2023-01-01
End Date:
2025-01-01
HLA-E restricted T-cell immunity in Mycobacterium tuberculosis infection
Grant Code:
R01/AI141315
Source of funding:
NIH
Amount:
49500
Role:
Researcher
Start Date:
2020-01-01
End Date:
2021-01-01
Contribution of the CD153/CD30 axis to Mycobacterium tuberculosis control in humans
Grant Code:
R21AI148027
Source of funding:
NIH
Amount:
275000
Role:
Principal Investigator
Start Date:
2019-01-01
End Date:
2021-01-01
Adaptive responses to SARS-CoV-2 variants in the context of hybrid immunity and immune impairment
Grant Code:
226137/Z/22/Z
Source of funding:
Wellcome Trust
Amount:
638204
Role:
Researcher
Start Date:
2023-01-01
End Date:
2025-01-01
Development of a blood-based assay to diagnose subclinical tuberculosis
Grant Code:
Crick - Idea to innovation (i2i)
Source of funding:
The Francis CRICK institut
Amount:
75000
Role:
Researcher
Start Date:
2020-01-01
End Date:
2021-01-01

Publications

Phenotypic Profile of Mycobacterium tuberculosis-Specific CD4 T-Cell Responses in People With Advanced Human Immunodeficiency Virus Who Develop Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome
Authors:
Date:
2022-10-17
Journal:
Open Forum Infectious Diseases
Content:
Disease extent and anti-tubercular treatment response correlates with Mycobacterium tuberculosis-specific CD4 T-cell phenotype regardless of HIV-1 status
Authors:
Date:
2020-09-28
Journal:
Clinical Translational Immunology
Content:
Immune network analysis reveals interleukin-17A related responses as key contributors to HIV-1 associated tuberculosis.
Authors:
Date:
2021-08-01
Journal:
Lancet Microbe
Content:
Host resistance to pulmonary Mycobacterium tuberculosis infection requires CD153 expression.
Authors:
Sallin, MA
Kauffman, K
Riou, C
Du Bruyn, E
Foreman, TW
Sakai, S
Hoft, SG
Myers, TG
Gardina, PJ
Sher, A
Moore, R
Wilder-Kofie, T
Moore, IN
Sette, A
Lindestam Arlehamn, CS
Wilkinson, RJ
Barber, DL
Date:
2018-11-03
Journal:
Nat Microbiol
Content:
Immunological correlates of the HIV-1 replication-competent reservoir size
Authors:
Date:
2021-10-15
Journal:
Clinical Infectious Diseases
Content:
Th22 Cells Are a Major Contributor to the Mycobacterial CD4+ T Cell Response and Are Depleted During HIV Infection
Authors:
Rubina Bunjun , author
Fidilia M. A. Omondi , author
Mohau S. Makatsa , author
Roanne Keeton , author
Jerome M. Wendoh , author
Tracey L. Müller , author
Caryn S. L. Prentice , author
Robert J. Wilkinson , author
Catherine Riou , author
Wendy A. Burgers , author
Date:
2021-09-01
Journal:
The Journal of Immunology
Content:
Dysregulation of the Immune Environment in the Airways During HIV Infection
Authors:
Bunjun R
Soares AP
Thawer N
Müller TL
Kiravu A
Ginbot Z
Corleis B
Murugan BD
Kwon DS
von Groote-Bidlingmaier F
Riou C
Wilkinson RJ
Walzl G
Burgers WA
Date:
2021-06-30
Journal:
Frontiers in Immunology
Content:
Blood and Site of Disease Inflammatory Profiles Differ in Patients With Pericardial Tuberculosis and Human Immunodeficiency Virus Type 1
Authors:
Date:
2023-03-09
Journal:
Open Forum Infec Dis
Content:
T cell responses to SARS-CoV-2 spike cross-recognize Omicron
Authors:
Date:
2022-01-31
Journal:
Nature
Content:
Rapid, simplified whole blood-based multiparameter assay to quantify and phenotype SARS-CoV-2 specific T cells
Authors:
Riou Catherine
Schäfer Georgia
du Bruyn Elsa
Goliath Rene T.
Stek Cari
Mou Huihui
Hung Deli
Wilkinson Katalin A.
Wilkinson Robert J.
Date:
2021-06-17
Journal:
Content:
Dysregulation of the immune environment in the airways during HIV infection.
Authors:
Date:
2021-06-30
Journal:
Frontiers in Immunology
Content:
Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner
Authors:
Keeton R
Richardson SI
Moyo-Gwete T
Hermanus T
Tincho M
Benede N
Manamela NP
Baguma R
Makhado Z
Ngomti A
Motlou T
Mennen M
Chinhoyi RL
Skelem S
Maboreke H
Doolabh D
Iranzadeh A
Otter AD
Brooks T
Noursadeghi M
Moon JC
Grifoni A
Weiskopf D
Sette A
Blackburn J
Hsiao N
Williamson C
Riou C
Goga A
Garrett N
Bekker L
Gray G
Ntusi N
Moore PL
Burgers W
Date:
2021-11-01
Journal:
Cell Host and Microbe
Content:
Comparison of the frequency and phenotypic profile of Mycobacterium tuberculosis-specific CD4 T cells between the site of disease and blood in pericardial tuberculosis
Authors:
Date:
2022-11-11
Journal:
Frontiers in Immunology
Content:
Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis
Authors:
Du Bruyn E
Ruzive S
Lindestam Arlehamn CS
Sette A
Sher A
Barber DL
Wilkinson RJ
Riou C
Date:
2020-07-16
Journal:
Mucosal Immunology
Content:
Relationship of SARS-CoV-2-specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfection
Authors:
Date:
2021-05-04
Journal:
Journal of Clinical Investigation
Content:
Histone acetylome-wide associations in immune cells from individuals with active Mycobacterium tuberculosis infection
Authors:
Ricardo C. H. del Rosario , author
Jeremie Poschmann , author
Carey Lim , author
Catherine Y. Cheng , author
Pavanish Kumar , author
Catherine Riou , author
Seow Theng Ong , author
Sherif Gerges , author
Hajira Shreen Hajan , author
Dilip Kumar , author
Mardiana Marzuki , author
Xiaohua Lu , author
Andrea Lee , author
Giovani Claresta Wijaya , author
Nirmala Arul Rayan , author
Zhong Zhuang , author
Elsa Du Bruyn , author
Cynthia Bin Eng Chee , author
Bernett Lee , author
Josephine Lum , author
Francesca Zolezzi , author
Michael Poidinger , author
Olaf Rotzschke , author
Chiea Chuen Khor , author
Robert J. Wilkinson , author
Yee T. Wang , author
George K Chandy , author
Gennaro De Libero , author
Amit Singhal , author
Shyam Prabhakar , author
Date:
2022-02-01
Journal:
Nature Microbiology
Content:
Kaposi's Sarcoma-Associated Herpesvirus, but Not Epstein-Barr Virus, Co-infection Associates With Coronavirus Disease 2019 Severity and Outcome in South African Patients
Authors:
Date:
2022-01-06
Journal:
Frontiers in Immunology
Content:
Residual T cell activation and skewed CD8+ T cell memory differentiation despite antiretroviral therapy-induced HIV suppression
Authors:
Date:
2018-10-01
Journal:
Clinical immunology
Content:
Impact of SARS-CoV-2 exposure history on the T cell and IgG response
Authors:
Date:
2023-01-17
Journal:
Cell Reports Medicine
Content:
Eosinophils are part of the granulocyte response in tuberculosis and promote host resistance in mice
Authors:
Bohrer Andrea C.
Castro Ehydel
Hu Zhidong
Queiroz Artur T.L.
Tocheny Claire E.
Assmann Maike
Sakai Shunsuke
Nelson Christine
Baker Paul J.
Ma Hui
Wang Lin
Zilu Wen
du Bruyn Elsa
Riou Catherine
Kauffman Keith D.
Moore Ian N.
Del Nonno Franca
Petrone Linda
Goletti Delia
Martineau Adrian R.
Lowe David M.
Cronan Mark R.
Wilkinson Robert J.
Barry Clifton E.
Via Laura E.
Barber Daniel L.
Klion Amy D.
Andrade Bruno B.
Song Yanzheng
Wong Ka-Wing
Mayer-Barber Katrin D.
{name=Tuberculosis Imaging Program
sequence=additional
affiliation=[]}
Date:
2021-08-04
Journal:
Content:
The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons
Authors:
Date:
2018-02-28
Journal:
Annu Rev Immunol
Content:
Prior infection with SARS-CoV-2 variants differentially boosts and broadens Ad26.COV2.S immunogenicity
Authors:
Date:
2021-11-10
Journal:
Cell Host & Microbe
Content:
Escape from recognition of SARS-CoV-2 variant spike epitopes but overall preservation of T cell immunity
Authors:
Catherine Riou , author
Roanne Keeton , author
Thandeka Moyo-Gwete , author
Tandile Hermanus , author
Prudence Kgagudi , author
Richard Baguma , author
Ziyaad Valley-Omar , author
Mikhail Smith , author
Houriiyah Tegally , author
Deelan Doolabh , author
Arash Iranzadeh , author
Lynn Tyers , author
Hygon Mutavhatsindi , author
Marius B. Tincho , author
Ntombi Benede , author
Gert Marais , author
Lionel R. Chinhoyi , author
Mathilda Mennen , author
Sango Skelem , author
Elsa du Bruyn , author
Cari Stek , author
Tulio de Oliveira , author
Carolyn Williamson , author
Penny L. Moore , author
Robert J. Wilkinson , author
Ntobeko A. B. Ntusi , author
Wendy A. Burgers , author
Date:
2022-02-09
Journal:
Science Translational Medicine
Content:
Effects of tuberculosis and/or HIV-1 infection on COVID-19 presentation and immune response in Africa
Authors:
Date:
2023-01-12
Journal:
Nature Communications
Content:
Disease extent and anti‐tubercular treatment response correlates with Mycobacterium tuberculosis ‐specific CD4 T‐cell phenotype regardless of HIV‐1 status
Authors:
Catherine Riou , author
Elsa Du Bruyn , author
Sheena Ruzive , author
Rene T Goliath , author
Cecilia S Lindestam Arlehamn , author
Alessandro Sette , author
Alan Sher , author
Daniel L Barber , author
Robert J Wilkinson , author
Date:
2020-01-01
Journal:
Clinical & Translational Immunology
Content:
Effects of tuberculosis and/or HIV-1 infection on COVID-19 presentation and immune response in Africa
Authors:
Date:
2023-01-12
Journal:
nature communications
Content:
Escape from recognition of SARS-CoV-2 Beta variant spike epitopes but overall preservation of T cell immunity
Authors:
Date:
2021-12-21
Journal:
Science Translational Medicine
Content:
Rapid, simplified whole blood-based multiparameter assay to quantify and phenotype SARS-CoV-2 specific T cells
Authors:
Date:
2022-01-13
Journal:
Eur Respir J
Content:
Th22 cells are a major contributor to the mycobacterial CD4+ T cell response and are depleted during HIV infection
Authors:
Date:
2021-09-01
Journal:
Journal of Immunology
Content:
CD153 expression by CD4 T cells is required for control of pulmonary Mycobacterium tuberculosis infection
Authors:
Date:
2018-11-03
Journal:
Nature Microbiology
Content:
Breakthrough infections with SARS-CoV-2 Omicron variant despite booster dose of mRNA vaccine
Authors:
Date:
2022-01-18
Journal:
The Lancet
Content:
Tuberculosis Antigen-Specific T-Cell Responses During the First 6 Months of Antiretroviral Treatment
Authors:
Riou, C
Jhilmeet, N
Rangaka, MX
Wilkinson, RJ
Wilkinson, KA
Date:
2020-01-01
Journal:
J Infect Dis
Content:
Immunological correlates of the HIV-1 replication-competent reservoir size
Authors:
Ismail Sherazaan D
Riou Catherine
Joseph Sarah B
Archin Nancie M
Margolis David M
Perelson Alan S
Cassidy Tyler
Abrahams Melissa-Rose
Moeser Matthew
Council Olivia D
McKinnon Lyle R
Osman Farzana
Abdool Karim Quarraisha
Abdool Karim Salim S
Swanstrom Ronald
Williamson Carolyn
Garrett Nigel J
Burgers Wendy A
Date:
2021-06-28
Journal:
Content:
Eosinophils are an integral component of the pulmonary granulocyte response in Tuberculosis and promote host resistance in mice
Authors:
Date:
2021-10-04
Journal:
J Exp Med
Content:
Blood and Site of Disease Inflammatory Profiles Differ in Patients With Pericardial Tuberculosis and Human Immunodeficiency Virus Type 1.
Authors:
Date:
2023-03-09
Journal:
Open Forum Infect Dis.
Content:
Profile of SARS-CoV-2-specific CD4 T cell response: Relationship with disease severity and impact of HIV-1 and active Mycobacterium tuberculosis co-infection
Authors:
Catherine Riou , author
Elsa du Bruyn , author
Cari Stek , author
Remy Daroowala , author
Rene T. Goliath , author
Fatima Abrahams , author
Qonita Said-Hartley , author
Brian W. Allwood , author
Marvin Hsiao , author
Katalin A. Wilkinson , author
Cecilia S. Lindestam Arlehamn , author
Alessandro Sette , author
Sean Wasserman , author
Robert J. Wilkinson , author
Date:
2021-02-20
Journal:
Content:
Relationship of SARS-CoV-2–specific CD4 response to COVID-19 severity and impact of HIV-1 and tuberculosis coinfection
Authors:
Riou Catherine
du Bruyn Elsa
Stek Cari
Daroowala Remy
Goliath Rene T.
Abrahams Fatima
Said-Hartley Qonita
Allwood Brian W.
Hsiao Nei-Yuan
Wilkinson Katalin A.
Arlehamn Cecilia S. Lindestam
Sette Alessandro
Wasserman Sean
Wilkinson Robert J.
Date:
2021-06-15
Journal:
Content:
Comparison of the frequency and phenotypic profile of Mycobacterium tuberculosis-specific CD4 T cells between the site of disease and blood in pericardial tuberculosis
Authors:
Date:
2023-02-06
Journal:
Frontiers in Immunology
Content:
Inflammatory profile of patients with tuberculosis with or without HIV-1 co-infection: a prospective cohort study and immunological network analysis
Authors:
Du Bruyn E
Fukutani KF
Rockwood N
Schutz C
Meintjes G
Arriaga MB
Cubillos-Angulo JM
Tibúrcio R
Sher A
Riou C
Wilkinson KA
Andrade BB
Wilkinson RJ
Date:
2021-08-01
Journal:
Lancet Microbe
Content:
Kaposi's Sarcoma-Associated Herpesvirus, but Not Epstein-Barr Virus, Co-infection Associates With Coronavirus Disease 2019 Severity and Outcome in South African Patients
Authors:
Melissa J Blumenthal, Humaira Lambarey, Abeen Chetram, Catherine Riou, Robert J Wilkinson , Georgia Schäfer
Date:
2022-01-06
Journal:
Front Microbiol
Content:
Derivation of a high-resolution CT-based, semi-automated radiographic score in tuberculosis and its relationship to bacillary load and antitubercular therapy
Authors:
Date:
2023-09-21
Journal:
Eur resp J
Content:

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