Dr Photini Kiepiela
| Call | Senior Fellowship (SF) |
| Programme | EDCTP1 |
| Start Date | 2010-03-25 |
| End Date | 2014-12-31 |
| Project Code | TA.2008.40200.015 |
| Status | Completed |
Title
Training in mucosal immunity and the evaluation of KIR:nHLA genes in HIV-1 clade c infection: key components to HIV vaccine design
Objectives
To answer questions relating to the role of host HLA and KIR genotype as HLA class I contributes to both the innate and adaptive immune responses
Host Organisation
| Institution | Country |
|---|---|
| South African Medical Research Council (SAMRC) | South Africa |
Participants
| Name | Institution | Country |
|---|---|---|
| S. Ganesh | South African Medical Research Council (SAMRC) | South Africa |
| Sharika Gappoo | South African Medical Research Council (SAMRC) | South Africa |
| Thumbi Ndungu | University of KwaZulu-Natal, South Africa | South Africa |
| Thesla Palanee | South African Medical Research Council (SAMRC) | South Africa |
| Jo-Anne Passmore | University of Cape Town (UCT) | South Africa |
| Gita Ramjee | South African Medical Research Council (SAMRC) | South Africa |
Study Design
Laboratory analyses of HIV mucosal immunity and KIR:HLA genes
Results & Outcomes
KIR: HLA genotyping was performed on a total of 557 HIV-1 exposed individuals, 142 of whom acquired HIV-1 infection and 415 remained HIV-1 negative over a 2 year period. There was a higher frequency of 2DS2+C1 gene combination in HIV-1 infected individuals compared to HIV-1 exposed seronegative (59%vs48%) and those individuals harbouring this KIR: HLA ligand combination were 1.5 times more likely to acquire HIV-1 infection. Certain KIR: HLA ligand associations (2DS2+C1) are significantly linked with susceptibility to HIV-1 infection. Four successful e-learning workshops were conducted at which 74 postgraduate students were trained. A “HDI” (Host Defense Interactions http://hdi.bio-med.ch) portal was established in collaboration with Prof JP Kreahenbuhl from HSeT.
Current Organisation
South African Medical Research Council
Grants
Publications
Authors:
Reddy S, Reddy T, Ntoyanto S, Sakadavan Y, Spooner E, Ramjee G, Ngomane N, Coutsoudis A, Kiepiela, P
, Reddy S et al. The accuracy, sensitivity and specificity of rapid point-of-care (POC) testing for TB diagnosis using the loop mediated isothermal assay (TB LAMP) in TB suspects. IJTLD 2017; http://dx.doi.org/10.5588/ijtld.16.0863
Date:
2017-06-27
Journal:
International Journal of Tubercle and Lund Disease
Content:
Identifiers:
Authors:
Leitman E, Thobakgale C, Adland E, Ansari M, Raghwani J, Prendergast A, Tudor-Williams G, Kiepiela P, Hemelaar J, Brener J, Tsai MH, Mori M, Riddell L, Luzzi G, Jooste P, Ndung'u T, Walker B, Pybus O, Kellam P, Naranbhai V, Matthews P, Gall A, and Goulder P
, Leitman E et al. Role of HIV-specific CD8+ T-cells in paediatric HIV cure strategies following widespread early viral escape. The Journal of Experimental Medicine
Date:
2017-06-20
Journal:
The Journal of Experimental Medicine
Content:
Identifiers:
Projects
Fellow:
Photini Kiepiela
Collaborators:
| Name | Country | Institution |
|---|---|---|
| Prof C Tiemessen (PI) | South Africa | WHC NICD |
Objectives:
The aim of this study is to establish a pipeline of key targets, both viral and host, which can be developed as future feasible therapeutic approaches for attaining a “functional cure” or ultimately an “eradicating cure” for HIV-1.
Sites:
Soweto, Durban
Subjects:
100 Elite Controllers; 200 Rapid Progressors
Outcomes:
Pending
Linked Grant:
“HIV-1 positive South African elite and long term controllers: viral and host targets for functional
Start Date:
2017-09-01
End Date:
2018-09-30