EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2021-07-01
End Date 2024-06-30
Project Code TMA2020CDF-3166
Status Active

Title

Investigating the multiple risk dimensions associated with Campylobacteriosis - a key poverty-related disease of South African urban source water environments

Objectives

1. To explore the social determinants, including sanitation-related service delivery failure related to Campylobacteriosis risk 2. To integrate metagenomics and MLA to develop predictive models of risks to human health occasioned by Campylobacter species contamination of source waters 3. To investigate ecological drivers of the persistence of Campylobacter species in contaminated source water, and relate these to risk and poverty mapping in the selected study areas 4. To integrate the outcomes of objectives 1-3 into a comprehensive risk assessment framework that draws on microbial ecology, risk and poverty mapping, NGS, and MLA and social drivers of exposure to Campylobacter spp.

Host Organisation

Institution Country
Rhodes University South Africa

Study Design

(i) explore the link between incidences of Campylobacteriosis and social determinants, including sanitation-related service delivery failure (ii)explore ecological and social determinants of human health risk associated with exposure to Campylobacter-contaminated source water iii) understand whether microplastics drive the persistence of antibiotic-resistant Campylobacter spp and their genes in source water and thus potential risk ; (iv) integrate of Shotgun metagenomics and machine learning algorithm into comprehensive microbial risk assessment and development of predictive models for risk of Campylobacteriosis in the source water

Sites

Nelson Mandela Bay Municipality
Makana Local Municipality

Students Supervised

Type Name Title University Start Date End Date
PhD Mary Chibwe Ms Rhodes University 2021 2023

Current Organisation

Rhodes University

Current Job Title

Researcher

Education

Institution Degree Year
University of KwaZulu Natal, South Africa PhD Microbiology 2017-03-07
University of KwaZulu Natal, South Africa MSc Biological Science 2010-04-20
University of KwaZulu Natal, South Africa Honours Biological Science 2006-05-08
Imo State University, Nigeria Bachelor of Science (Hons) in Industrial Microbiology 2001-12-30

Publications

Projects

Fellow:
Chika Felicitas Nnadozie
Collaborators:
Name Country Institution
Dr Chika Felicitas Nnadozie (principal investigator) South Africa Rhodes University
Prof Oghenekaro Nelson Odume (mentor) South Africa Rhodes University
Ms Khaya Mgaba South Africa Rhodes University
Ms Mary Chibwe South Africa Rhodes University
Objectives:
(i) To explore the social determinants, including sanitation-related service delivery failure related to Campylobacteriosis risk (2) To integrate metagenomics and machine learning algorithms (MLA) in order to develop predictive models of risks to human health occasioned by Campylobacter species contamination of source water (3) To investigate ecological drivers of the persistence of Campylobacter species in contaminated source water and relate these to risk and poverty mapping in the selected study areas (4)To integrate the outcomes of objectives 1-3 into a comprehensive risk assessment framework
Sites:
Study area A: Kowie River in Makana Municipality, Eastern Cape province of South Africa. The Makana Local Municipality Municipality, Eastern Cape, South Africa supports about 80 390 people. Unlike the NMBM, there are a limited number of employment opportunities available in the cities particularly Grahamstown of the Makana Local Municipality. There is a high level of poverty within the area, with up to 42% of the households without income compared to NMBM.The lack of revenue collection restricts the Municipality from providing local service delivery and Infrastructure such as wastewater treatment plants (WWTP) breakdown. This problem of infrastructure breakdown has resulted in health threatening sewage spills, water shortages, and refuses removal failure. Most of the sewage flow into the Kowie River, which is in Grahamston, a town in Makana Local Municipality. Study Area B: Swartkops River in Nelson Mandela Bay Municipality (NMBM), , Eastern Cape province of South Africa. NMBM supports about 1.2 million people. NMBM encompasses the city of Port Elizabeth and the towns of Uitenhage and Despatch. As the industrial hub of the Eastern Cape province of South Africa, there are higher employment rates and access to municipal services. The increasing population and industrial activities have led to the serious pollution of the Swartkops River. The Swartkops River is a popular ecological and social cultural asset and is located within the industrial city of Port Elizabeth and Uitenhage town. The pollution results from burst sewerage pipes, residents dumping in the canal, open canal flows through Motherwell stormwater canal and overloaded Kelven Jones wastewater treatment works.
Study Design:
This project will combine multiple approaches: Next generation sequencing, machine learning algorithms, microbial ecology, and risk mapping to attempt an integrated study of Campylobacteriosis-a key PRD in South African urban freshwater environments
Subjects:
TMA2020CDF-3166
Outcomes:
(i)A most important outcome of this project is the protocol development, risk assessment framework (ii)Publications (iii) Msc Thesis (iv)Phd progress report (v)Workshops (vi) Beyond the lifespan of the project, I intend to use workshops to disseminate the risk framework and metagenomics-MLA protocol developed in this project.
Start Date:
2021-07-01
End Date:
2024-06-30

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