Dr Pauline Mwinzi
| Call | Senior Fellowship (SF) |
| Programme | EDCTP1 |
| Start Date | 2009-11-24 |
| End Date | 2011-11-24 |
| Project Code | TA.2008.40200.007 |
| Status | Completed |
Title
Immune reconstitution inflammatory syndrome (IRIS) in schistosomiasis patients undergoing HAART
Objectives
To study the Immunopathogenesls, clinical aspects and management of manifestation of IRIS in HIV-schistosome co-infection patients undergoing HAART In western Kenya. Schistosome infections are common in the same areas where HIV prevalence is also high.
Host Organisation
| Institution | Country |
|---|---|
| Kenya Medical Research Institute (KEMRI) | Kenya |
Participants
| Name | Institution | Country |
|---|---|---|
| Robert Colebunders | Prince Leopold Institute of Tropical Medicine (ITM) | Belgium |
| Diana Karanja | Kenya Medical Research Institute (KEMRI) | Kenya |
| Luc Kestens | Prince Leopold Institute of Tropical Medicine (ITM) | Belgium |
| Erick Muok | Kenya Medical Research Institute (KEMRI) | Kenya |
| Katja Polman | Prince Leopold Institute of Tropical Medicine (ITM) | Kenya |
Study Design
Prevalence study on IRIS in schistomiasis on HAART
Results & Outcomes
622 HIV-positive patients were followed. In the first year of follow up 12 patients expressed signs and symptoms of IRIS of whom two met the case definition of IRIS. As a requirement for all staff participants on this project, GCP/GCLP training was provided online from the EDCTPsponsored AMANET online courses.
Publications
| Ogola GO, Ouma C, Jura WG, Muok EO, Colebunders R, Mwinzi PN. A non-synonymous polymorphism in IL-23R Gene (rs1884444) is associated with reduced risk to schistosomiasis-associated Immune Reconstitution Inflammatory Syndrome in a Kenyan population. BMC Infect Dis. 2014 Jun 10;14(1):316. doi:10.1186/1471-2334-14-316. |