Dr Rose Nabatanzi
| Call | Career Development Fellowship (CDF) |
| Programme | EDCTP2 |
| Start Date | 2021-07-01 |
| End Date | 2024-06-30 |
| Project Code | TMA2020CDF-3162 |
| Status | Active |
Title
Characterisation of the latent reservoir among HIV infected individuals on long term antiretroviral therapy (LIIT)
Host Organisation
| Institution | Country |
|---|---|
| Makerere University - Biomedical Research Centre | Uganda |
Current Organisation
Makerere University College of Health Sciences
Current Job Title
Research Scientist
Students Supervised
| Type | Name | Title | University | Start Date | End Date |
|---|---|---|---|---|---|
| MSC | Moreen Namuyanja | DEVELOPMENT OF AN IN- HOUSE IgM AND IgG ELISA FOR DETECTION OF EXPOSURE TO SARS-COV2 | Makerere University | 2021 | 2022 |
| MSC | Richard Otim | Characterization of Performance of Three Commercial Monoclonal Antibodies in Detection of Spike Protein in SARS-Cov-2 | Makerere University | 2021 | 2022 |
| MSC | Waiswa Daniel | SARS-CoV-2 Immune Responses induced by Infection and/or Vaccination among HIV infected individuals in Kampala Uganda. | Makerere University | 2022 | 2023 |
| MSC | Victor Muhumuza | To Explore changes in antibody responses and T cell function among COVID-19 patients | Makerere University | 2022 | 2023 |
| MSC | Patricia Kankundiye | Immune responses in SARS-COV 2 infection; Biomarkers for Severe Disease | Makerere University | 2022 | 2023 |
| MSC | Mutesi Naume | Effect of SARS-CoV-2 infection on Immune responses to HPV infection among HIV infected women | Makerere University | 2022 | 2023 |
| MSC | Diana Sitenda | IMMUNE AND VACCINE RESPONSES OF INFANTS BORN TO ACTIVE TB MOTHERS | Makerere University | 2022 | 2023 |
Education
| Institution | Degree | Year |
|---|---|---|
| Makerere University, Uganda | PhD | 2020-01-14 |
| Makerere University, Uganda | MSC | 2015-01-13 |
| Makerere University, Uganda | BSC | 2005-10-11 |
Areas Of Specialisation
Human Immuno-deficiency Virus (HIV)
Publications
Authors:
Nabatanzi R
, author
Bayigga L , author
Cose S , author
Canderan G , author
Rowland Jones S , author
Joloba M , author
Nakanjako D , author
Bayigga L , author
Cose S , author
Canderan G , author
Rowland Jones S , author
Joloba M , author
Nakanjako D , author
Date:
2021-08-26
Journal:
BMC immunology
Content:
Background
Innate lymphoid cells (ILC) are lymphoid lineage innate immune cells that do not mount antigen-specific responses due to their lack of B and T-cell receptors. ILCs are predominantly found at mucosal surfaces, as gatekeepers against invading infectious agents through rapid secretion of immune regulatory cytokines. HIV associated destruction of mucosal lymphoid tissue depletes ILCs, among other immune dysfunctions. Studies have described limited restoration of ILCs during the first three years of combined antiretroviral therapy (cART). Little is known about restoration of ILCs during long-term cART, particularly in sub-Saharan Africa which hosts increasing numbers of adults with at least a decade of cART.Results
We examined phenotypes and function of ILCs from peripheral blood mononuclear cells after 12 years of suppressive cART. We report that ILC1 frequencies (T-BET + CD127 + and CD161 +) were higher in cART-treated HIV-infected relative to age-matched health HIV-negative adults; P = 0.04 whereas ILC precursors (ILCP) were comparable in the two groups (P = 0.56). Interferon gamma (IFN-γ) secretion by ILC1 was higher among cART-treated HIV-infected relative to HIV-negative adults (P = 0.03).Conclusion
HIV associated alteration of ILC persisted during cART and may likely affect the quality of host innate and adaptive immune responses during long-term cART.Identifiers:
Authors:
Date:
2021-01-01
Journal:
Highlights on Medicine and Medical Science Vol. 4
Content:
Identifiers: