EDCTP Alumni Network

Title

Malaria baseline studies towards characterising and establishing a clinical trial site at Mutengene, South West Region of Cameroon

Objectives

The epidemiological study was designed to provide data on baseline malariometric parameters valuable for future intervention studies aimed at validating disease control tools. The specific objectives include conducting a population census of the study area, determining the malaria prevalence rates and density in cross sectional surveys, helminth and malaria co-infection rates and densities, number of episodes per year in cohort longitudinal studies, vectors transmitting parasites, their dynamics and inoculation rates, natural immune responses to malaria parasite exposure and prevalence of some genetic traits that protect against malaria.

Host Organisation

Institution	Country
University of Buea	Cameroon

Participants

Name	Institution	Country
Julius Atashili	University of Buea	Cameroon

Study Design

Epidemiological studies for clinical trials site development

Sites

Mutengene, Fako Division (Cameroon)

Results & Outcomes

At the end of the project a total of 15,344 individuals were included and a series of baseline studies were conducted. These included studies on household mosquito net ownership, prevalence of fever, prevalence of malaria parasitaemia by season, prevalence of intestinal helminthes by season, prevalence of anaemia, the prevalence of the sickle cell trait (HbAS) in the study group and levels of Plasmodium falciparum specific IgE/IgG2 antibodies in study participants. The project is well integrated within the EDCTP-funded central African network of excellence, CANTAM, and also received additional funding from the European Virtual Institute for Malaria Research (EVIMalaR). Eight members of the study team received various short term trainings.

Publications

Achidi EA, Apinjoh TO, Anchang-Kimbi JK, Yafi CN, Besingi R, Awah NW, Troye-Blomberg M. Plasmodium falciparum Specific IgE, IgG and Anti-GPI IgG Antibodies in Cameroonian Children with Severe and Uncomplicated Malaria. International Journal of Tropical Disease and Health. 2012 Jun; 2(3): 157-172

Achidi EA, Apinjoh TO, Anchang-Kimbi JK, Mugri RN, Ngwai AN, Yafi CN. Severe and uncomplicated falciparum malaria in children from three regions and three ethnic groups in Cameroon: prospective study. Malaria Journal 2012 Jun 24;11:215.

Tchinda GG, Atashili J, Achidi EA, Kamga HL, Njunda AL, Ndumbe PM. Impact of malaria on hematological parameters in people living with HIV/AIDS attending the Laquintinie Hospital in Douala, Cameroon. PLoS One. 2012;7(7):e40553. doi: Project Porftolio Page 378 of 622 10.1371/journal.pone.0040553. Epub 2012 Jul 10.