|Call||Senior Fellowship (SF)|
Functional characteristics of effector and memory NK cellular responses and their comparison with adaptive T cell responses in HIV-vaccinated subjects and risk populations
1. To determine if NK cell recall responses are elicited in HIV uninfected infants and infected adults who received HIV vaccine candidates 2. To determine if NK cell recall responses are present in HIVexposed but uninfected adults and in HIV sero-discordant couples. If present, we will characterise these responses (both the effector recall NK responses) 3. To determine the relationship between NK cell responses and the frequency and quality of CD4+ and CD8+ T cell responses in at-risk populations
|Medical Research Council (MRC) Laboratories||Gambia|
|Anders Fomsgaard||Statens Serum Institut, (SSI)||Denmark|
|Assan Jaye||Medical Research Council (MRC) Laboratories||Gambia|
|Souleymane Mboup||University Cheikh Anta DIOP de Dakar (UCAD)||Senegal|
|Eleanor Mary Riley||London School of Hygiene and Tropical Medicine (LSHTM)||United Kingdom|
|The Gambia, Guinea Bissau and Dakar|
A preliminary analysis or a pilot study has been performed on some of the samples from the discordant couples cohort in Senegal. This data shows that HIV peptides can activate NK functional responses in HIV-positive individuals; and that HIV exposed but uninfected subjects elicit higher NK functional responses (as measured by higher degranulation and higher interferon –gamma production); and less NK activation (lower CD25) as compared to those who are HIV-infected. These results have been presented nationally, regionally and internationally. In a recent international scientific meeting, the 17th Annual meeting of the International Conference on AIDS and STIs in Africa (ICASA), in Cape town, South Africa, the abstract on results from this preliminary study won one of the five best abstract awards; the “Best Young Investigators award for basic science.
National Institute of Communicable Diseases (NICD)
Human Immuno-deficiency Virus (HIV) Public Health Vaccine-preventable diseases
Primary B-cell immunodeficiencies are risk factors for the generation of vaccine-derived polioviruses. We report immunodeficiency-associated vaccine-derived poliovirus serotype 3 in an 11-week old boy with X-linked agammaglobulinemia. Unique characteristics of this case include early age of presentation, high viral evolutionary rate and that the child was perinatally exposed to HIV.
Human immunodeficiency virus (HIV)-exposed, uninfected infants have higher risks of respiratory syncytial virus-associated hospitalization than HIV-unexposed infants. Despite similar neutralizing antibody titers between HIV-infected and -uninfected women, maternal HIV infection and hypergammaglobulinemia were independently associated with lower titers in newborns. Maternal hypergammaglobulinemia was associated with lower cord-to-maternal antibody ratio.