EDCTP Alumni Network

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All Profiles

Mr Francis Mungathia Kobia

Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2020-11-01
End Date 2023-10-31
Project Code TMA2019CDF-2736
Status Active

Title

Targeting fetal-maternal innate response conflict for better placental malaria outcomes (IRMiP)

Host Organisation

Institution Country
Mount Kenya University Trust (MKU) Kenya

Current Organisation

Mount Kenya University

Current Job Title

Research Fellow

Students Supervised

Type Name Title University Start Date End Date
MSc Samuel Chenge JKUAT 2021
Harrison Ngure MKU 2021

Areas Of Specialisation

Malaria

Publications

Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling.
Authors:
Kobia F , author
Duchi S , author
Deflorian G , author
Vaccari T , author
Date:
2014-03-01
Journal:
Molecular oncology
Content:
Identifiers:
PMID: 24309677
PMC: PMC5528540
DOI: 10.1016/j.molonc.2013.11.002
Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster.
Authors:
Tognon E , author
Kobia F , author
Busi I , author
Fumagalli A , author
De Masi F , author
Vaccari T , author
Date:
2016-01-01
Journal:
Autophagy
Content:
Identifiers:
PMID: 26727288
PMC: PMC4836007
DOI: 10.1080/15548627.2015.1134080
The state of cancer in Meru, Kenya: a retrospective study [version 1; peer review: 1 approved with reservations, 1 not approved]
Authors:
Francis Kobia , author
Jesse Gitaka , author
Francis Makokha , author
Moses Kamita , author
Joshua Kibera , author
Cynthia Mwenda , author
Gladys Mucee , author
Bactrin Kilingo , author
Date:
2019-12-03
Journal:
Content:
Identifiers:
DOI: 10.12688/aasopenres.13027.1
Part of ISSN: 2515-9321
COVID-19: Are Africa’s diagnostic challenges blunting response effectiveness? [version 1; peer review: 2 approved]
Authors:
Francis Kobia , author
Jesse Gitaka , author
Date:
2020-04-17
Journal:
Content:
Identifiers:
DOI: 10.12688/aasopenres.13061.1
Part of ISSN: 2515-9321
Exposure to Mites Sensitizes Intestinal Stem Cell Maintenance, Splenic Marginal Zone B Cell Homeostasis, And Heart Development to Notch Dosage and Cooperativity
Authors:
Date:
2020-03-06
Journal:
[]
Content:
AbstractCooperative DNA binding is a key feature of transcriptional regulation. Here we examined the role of cooperativity in Notch signaling by CRISPR-mediated engineering of mice in which neither Notch1 nor Notch2 can homo- or heterodimerize, essential for cooperative binding to sequence paired sites (SPS) located near many Notch-regulated genes. While most known Notch-dependent phenotypes were unaffected in Notch1/2 dimer-deficient mice, a subset of tissues proved highly sensitive to loss of cooperativity. These phenotypes include heart development, compromising viability in combination with low gene dose, and the gut, developing ulcerative colitis in response to 1% DSS. The most striking phenotypes – gender imbalance and splenic marginal zone B cell lymphoma – emerged in combination with dose reduction or when challenged by chronic fur mite infestation. This study highlights the role of the environment in malignancy and colitis, and is consistent with Notch-dependent anti-parasite immune responses being compromised in the dimer deficient animals.HighlightsNotch dimerization has an in vivo role in contributing to intestinal homeostasisLoss of cooperativity can manifest as Notch gain or loss of function phenotypesMite infestation exacerbates all phenotypes, triggers MZB hyperproliferation in mutant animalsMite-infested mutant mice develop SMZL with age
Identifiers:
DOI: 10.1101/2020.02.13.948224
Potential pharmacologic interventions targeting TLR signaling in placental malaria
Authors:
Francis M. Kobia , author
Kaushik Maiti , author
Moses M. Obimbo , author
Roger Smith , author
Jesse Gitaka , author
Date:
2022-05-01
Journal:
Trends in Parasitology
Content:
Identifiers:
DOI: 10.1016/j.pt.2022.04.002
Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation
Authors:
Date:
2020-10-05
Journal:
PLOS Biology
Content:
Identifiers:
DOI: 10.1371/journal.pbio.3000850
Part of ISSN: 1545-7885

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