EDCTP Alumni Network

Title

Role of functionally distinct monocyte subpopulations in protection against clinical Plasmodium falciparum malaria in people living in endemic area of Mali

Objectives

To assess the role of monocytes activation by infected red blood cell in the protection against clinical falciparum malaria in endemic area and determine the frequency of monocytes subpopulations according to the clinical outcome (asymptomatic, mild and severe) of malaria infection

Host Organisation

Institution	Country
University of Bamako	Mali

Participants

Name	Institution	Country
Charles Aarama	Malaria Research & Training Center	Mali
Issa Diarra	Malaria Research & Training Center	Mali
Abdoulaye Kone	Malaria Research & Training Center	Mali
Amadou Niangaly	Malaria Research & Training Center	Mali
Mahamadou Sissoko	Malaria Research & Training Center	Mali
Kourane Sissoko	Malaria Research & Training Center	Mali

Study Design

Immunological cohort studies

Results & Outcomes

Antibody titres to all antigens, except MSP-119, and the number of antigens recognized increased with age. After malaria exposure, antibody titres increased in children that had low titres at baseline, but decreased in those with high baseline responses. No significant differences were found between antibody titers for individual antigens between children remaining symptomatic or asymptomatic after exposure, after adjustment for age. Instead, children remaining asymptomatic following parasite exposure had a broader repertoire of antigen recognition. The present study provides immuneepidemiological evidence from a limited cohort of Malian children that strong recognition of multiple antigens, rather than antibody titres for individual antigens, is associated with protection from clinical malaria.

Publications

Daou M, Kouriba B, Ouédraogo N, et al. Protection of Malian children from clinical malaria is associated with recognition of multiple antigens. Malaria Journal. 2015;14:56. doi:10.1186/s12936-015-0567-9.