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Professor Grant Theron

Call Senior Fellowship (SF)
Programme EDCTP2
Start Date 2017-04-01
End Date 2022-03-31
Project Code TMA2015SF1041
Status Active

Title

What is the feasibility, accuracy, and optimal manner in which next-generation tests for tuberculosis can be used in high-burden setting? (The OPTIMAL DIAGNOSIS study)

Objectives

To evaluate the point-of-care feasibility, accuracy and effectiveness of highly sensitive, next-generation diagnostics for the diagnosis of pulmonary TB, extra-pulmonary TB, and drug-resistant TB, whilst assembling a comprehensive, well-characterised biobank for the future research, training, and capacity development.

Host Organisation

Institution Country
Stellenbosch University (SU) South Africa

Study Design

Diagnostic evaluation

Students Supervised

Type Name Title University Start Date End Date
Post-doctoral fellow Byron Reeve Dr SU 2016 2021
PhD Stephanie Minnies Ms SU 2018 2021
PhD Samantha Pillay Ms SU 2016 2021
Post-doctoral fellow Charissa Naidoo Dr SU 2016 2021
PhD Georgina Nyawo Ms SU 2017 2021
PhD Gcobisa Nglangalavu Ms SU 2019 2021
PhD Yonas Ghebrekristos Mr SU 2020 2023
MSc Loren Rockman Ms SU 2019 2021

Publications

https://doi.org/10.1093/cid/ciaa873
https://doi.org/10.1016/S2214-109X(20)30227-8
https://doi.org/10.1016/ S2213-2600(19)30370-4
https://doi.org/10.1038/s41591-020-0940-2
https://www.nature.com/articles/s41598-020-59164-3

Current Organisation

Stellenbosch University

Awards

2019 Gertrud Meisner Award (European Society of Mycobacteriology)

Students Supervised

Type Name Title University Start Date End Date
Grant Theron

Publications

The child ecosystem and childhood pulmonary tuberculosis: A South African perspective
Authors:
Teresa DeAtley , author
Lesley Workman , author
Grant Theron , author
Sabine BĂ©lard , author
Margaretha Prins , author
Lindy Bateman , author
Martin P. Grobusch , author
Keertan Dheda , author
Mark P. Nicol , author
Katherine Sorsdahl , author
Caroline Kuo , author
Dan J. Stein , author
Heather J. Zar , author
Date:
2021-07-25
Journal:
Pediatric Pulmonology
Content:
Identifiers:
DOI: 10.1002/ppul.25369
Reimagining the status quo: How close are we to rapid sputum-free tuberculosis diagnostics for all?
Authors:
Ruvandhi R. Nathavitharana , author
Alberto L. Garcia-Basteiro , author
Morten Ruhwald , author
Frank Cobelens , author
Grant Theron , author
Date:
2022-04-01
Journal:
eBioMedicine
Content:
Identifiers:
DOI: 10.1016/j.ebiom.2022.103939
Still dying in plain sight: missed and misclassified deaths due to tuberculosis in hospitals
Authors:
Byron William Patrick Reeve , author
Rosella Centis , author
Grant Theron , author
Date:
2019-09-01
Journal:
European Respiratory Journal
Content:
Identifiers:
DOI: 10.1183/13993003.01578-2019
Wake-cough: Cough spotting and cougher identification for personalised long-term cough monitoring
Authors:
Pahar, M.
Klopper, M.
Reeve, B.
Warren, R.
Theron, G.
Diacon, A.
Niesler, T.R.
Date:
2021-01-01
Journal:
arXiv
Content:
Identifiers:
EID: 2-s2.0-85117794715
Part of ISSN: 23318422
Investigation of preanalytical variables impacting pathogen cell-free DNA in blood and urine
Authors:
Murugesan, K.
Hogan, C.A.
Palmer, Z.
Reeve, B.
Theron, G.
Andama, A.
Somoskovi, A.
Steadman, A.
Madan, D.
Andrews, J.
Croda, J.
Sahoo, M.K.
Cattamanchi, A.
Pinsky, B.A.
Banaei, N.
Date:
2019-01-01
Journal:
Journal of Clinical Microbiology
Content:
Identifiers:
DOI: 10.1128/JCM.00782-19
EID: 2-s2.0-85074118936
Part of ISBN: 1098660X 00951137
An automated tuberculosis screening strategy combining X-ray-based computer-aided detection and clinical information
Authors:
Date:
2016-01-01
Journal:
Content:
Identifiers:
Do adjunct TB tests, when combined with Xpert MTB/RIF, improve accuracy and the cost of diagnosis in a resource-poor setting?
Authors:
Date:
2011-01-01
Journal:
European Respiratory Journal
Content:
Identifiers:
DOI: 10.1183/09031936.00145511
EID: 2-s2.0-84863461477
Part of ISBN: 09031936 13993003
Comparison of isothermal microcalorimetry and BACTEC MGIT960 for the detection of the metabolic activity of Mycobacterium tuberculosis in sputum samples
Authors:
Date:
2020-01-01
Journal:
Journal of Applied Microbiology
Content:
Identifiers:
Sputum induction to aid diagnosis of smear-negative or sputum-scarce tuberculosis in adults in HIV-endemic settings
Authors:
Date:
2014-01-01
Journal:
European Respiratory Journal
Content:
Identifiers:
DOI: 10.1183/09031936.00198012
EID: 2-s2.0-84891908248
Part of ISBN: 09031936 13993003
Health care seeking patterns of rifampicin-resistant tuberculosis patients in Harare, Zimbabwe: A prospective cohort study
Authors:
Tadokera, R.
Huo, S.
Theron, G.
Timire, C.
Manyau-Makumbirofa, S.
Metcalfe, J.Z.
Date:
2021-01-01
Journal:
PLoS ONE
Content:
Identifiers:
DOI: 10.1371/journal.pone.0254204
EID: 2-s2.0-85110554933
Part of ISSN: 19326203
Cost-effectiveness of Xpert MTB/RIF and investing in health care in Africa
Authors:
Date:
2014-01-01
Journal:
The Lancet Global Health
Content:
Identifiers:
DOI: 10.1016/S2214-109X(14)70305-5
EID: 2-s2.0-84907279823
Part of ISBN: 2214109X
Point-of-Care Technologies for the Diagnosis of Active Tuberculosis
Authors:
Date:
2016-01-01
Journal:
Molecular Microbiology
Content:
Identifiers:
Evaluation of the airway microbiome in nontuberculous mycobacteria disease
Authors:
Sulaiman, I.
Wu, B.G.
Li, Y.
Scott, A.S.
Malecha, P.
Scaglione, B.
Wang, J.
Basavaraj, A.
Chung, S.
Bantis, K.
Carpenito, J.
Clemente, J.C.
Shen, N.
Bessich, J.
Rafeq, S.
Michaud, G.
Donington, J.
Naidoo, C.
Theron, G.
Schattner, G.
Garofano, S.
Condos, R.
Kamelhar, D.
Addrizzo-Harris, D.
Segal, L.N.
Date:
2018-01-01
Journal:
European Respiratory Journal
Content:
Identifiers:
DOI: 10.1183/13993003.00810-2018
EID: 2-s2.0-85055623898
Part of ISBN: 13993003 09031936
Impact of tuberculosis treatment and antiretroviral therapy on serial RD-1-specific quantitative T-cell readouts (QuantiFERON-TB Gold In-Tube), and relationship to treatment-related outcomes and bacterial burden
Authors:
Date:
2015-01-01
Journal:
International Journal of Infectious Diseases
Content:
Identifiers:
DOI: 10.1016/j.ijid.2015.05.006
EID: 2-s2.0-84931274678
Part of ISBN: 18783511 12019712
Anaerobe-enriched gut microbiota predicts pro-inflammatory responses in pulmonary tuberculosis
Authors:
Naidoo, C.C.
Nyawo, G.R.
Sulaiman, I.
Wu, B.G.
Turner, C.T.
Bu, K.
Palmer, Z.
Li, Y.
Reeve, B.W.P.
Moodley, S.
Jackson, J.G.
Limberis, J.
Diacon, A.H.
van Helden, P.D.
Clemente, J.C.
Warren, R.M.
Noursadeghi, M.
Segal, L.N.
Theron, G.
Date:
2021-01-01
Journal:
EBioMedicine
Content:
Identifiers:
DOI: 10.1016/j.ebiom.2021.103374
EID: 2-s2.0-85105446093
Part of ISSN: 23523964
Comparison of same day diagnostic tools including Gene Xpert and unstimulated IFN-$Îł$ for the evaluation of pleural tuberculosis: a prospective cohort study
Authors:
Date:
2014-01-01
Journal:
BMC pulmonary medicine
Content:
Identifiers:
DOI: 10.1186/1471-2466-14-58
EID: 2-s2.0-84899474205
Part of ISBN: 14712466
Comparison of two methods for acquisition of sputum samples for diagnosis of suspected tuberculosis in smear-negative or sputum-scarce people: a randomised controlled trial
Authors:
Date:
2013-01-01
Journal:
The Lancet Respiratory Medicine
Content:
Identifiers:
DOI: 10.1016/S2213-2600(13)70120-6
EID: 2-s2.0-84881368463
Part of ISBN: 22132600
Sensitivity of C-Tb: a novel RD-1-specific skin test for the diagnosis of tuberculosis infection
Authors:
Date:
2015-01-01
Journal:
European Respiratory Journal
Content:
Identifiers:
DOI: 10.1183/13993003.01464-2015
EID: 2-s2.0-84959891548
Part of ISBN: 13993003 09031936
Xpert MTB/RIF as a measure of sputum bacillary burden. Variation by HIV status and immunosuppression
Authors:
Date:
2014-01-01
Journal:
American journal of respiratory and critical care medicine
Content:
Identifiers:
DOI: 10.1164/rccm.201312-2140OC
EID: 2-s2.0-84901811250
Part of ISBN: 15354970 1073449X
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis
Authors:
Date:
2017-01-01
Journal:
The Lancet Respiratory Medicine
Content:
Identifiers:
Drug-resistant tuberculosis in 2017: at a crossroads
Authors:
Date:
2017-01-01
Journal:
The Lancet Respiratory Medicine
Content:
Identifiers:
Guidance for Studies Evaluating the Accuracy of Sputum-Based Tests to Diagnose Tuberculosis
Authors:
Schumacher, S.G.
Wells, W.A.
Nicol, M.P.
Steingart, K.R.
Theron, G.
Dorman, S.E.
Pai, M.
Churchyard, G.
Scott, L.
Stevens, W.
Nabeta, P.
Alland, D.
Weyer, K.
Denkinger, C.M.
Gilpin, C.
Date:
2019-01-01
Journal:
Journal of Infectious Diseases
Content:
Identifiers:
DOI: 10.1093/infdis/jiz258
EID: 2-s2.0-85073065126
Part of ISBN: 15376613 00221899
Diagnostic accuracy of the FluoroType MTB and MTBDR VER 2.0 assays for the centralized high-throughput detection of Mycobacterium tuberculosis complex DNA and isoniazid and rifampicin resistance
Authors:
Dippenaar, A.
Derendinger, B.
Dolby, T.
Beylis, N.
van Helden, P.D.
Theron, G.
Warren, R.M.
de Vos, M.
Date:
2021-01-01
Journal:
Clinical Microbiology and Infection
Content:
Identifiers:
DOI: 10.1016/j.cmi.2021.04.022
EID: 2-s2.0-85107660405
Part of ISSN: 14690691 1198743X
The diagnostic accuracy of pericardial and urinary lipoarabinomannan (LAM) assays in patients with suspected tuberculous pericarditis
Authors:
Date:
2016-01-01
Journal:
Scientific Reports
Content:
Identifiers:
Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study
Authors:
Date:
2015-01-01
Journal:
BMC infectious diseases
Content:
Identifiers:
DOI: 10.1186/s12879-015-0964-2
EID: 2-s2.0-84934271619
Part of ISBN: 14712334
Automatic cough classification for tuberculosis screening in a real-world environment
Authors:
Madhurananda Pahar , author
Marisa Klopper , author
Byron Reeve , author
Rob Warren , author
Grant Theron , author
Thomas Niesler , author
Date:
2021-10-01
Journal:
Physiological Measurement
Content:
Identifiers:
DOI: 10.1088/1361-6579/ac2fb8
Can point-of-care urine LAM strip testing for tuberculosis add value to clinical decision making in hospitalised HIV-infected persons?
Authors:
Date:
2013-01-01
Journal:
PloS one
Content:
Identifiers:
DOI: 10.1371/journal.pone.0054875
EID: 2-s2.0-84873499578
Part of ISBN: 19326203
Effect on mortality of point-of-care, urine-based lipoarabinomannan testing to guide tuberculosis treatment initiation in HIV-positive hospital inpatients: a pragmatic, parallel-group, multicountry, open-label, randomised controlled trial
Authors:
Date:
2016-01-01
Journal:
The Lancet
Content:
Identifiers:
DOI: 10.1016/S0140-6736(15)01092-2
EID: 2-s2.0-84961212860
Part of ISBN: 1474547X 01406736
Automated chest-radiography as a triage for Xpert testing in resource-constrained settings: a prospective study of diagnostic accuracy and costs
Authors:
Date:
2015-01-01
Journal:
Scientific reports
Content:
Identifiers:
DOI: 10.1038/srep12215
EID: 2-s2.0-84938261223
Part of ISBN: 20452322
Cost-effectiveness of post-treatment follow-up examinations and secondary prevention of tuberculosis in a high-incidence setting: a model-based analysis
Authors:
Marx, F.M.
Cohen, T.
Menzies, N.A.
Salomon, J.A.
Theron, G.
Yaesoubi, R.
Date:
2020-01-01
Journal:
The Lancet Global Health
Content:
Identifiers:
DOI: 10.1016/S2214-109X(20)30227-8
EID: 2-s2.0-85089544133
Part of ISBN: 2214109X
Automatic Detection of Tuberculosis in Chest Radiographs Using a Combination of Textural, Focal, and Shape Abnormality Analysis
Authors:
Date:
2015-01-01
Journal:
IEEE Transactions on Medical Imaging
Content:
Identifiers:
Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous pericarditis compared to adenosine deaminase and unstimulated interferon-$Îł$ in a high burden setting: a prospective study
Authors:
Date:
2014-01-01
Journal:
BMC medicine
Content:
Identifiers:
DOI: 10.1186/1741-7015-12-101
EID: 2-s2.0-84902302542
Part of ISBN: 17417015
Xpert MTB/RIF to diagnose tuberculosis in children
Authors:
Date:
2015-01-01
Journal:
The Lancet Respiratory Medicine
Content:
Identifiers:
DOI: 10.1016/S2213-2600(15)00111-3
EID: 2-s2.0-84930868526
Part of ISBN: 22132619 22132600
Diagnostic accuracy of a urine lipoarabinomannan strip-test for TB detection in HIV-infected hospitalised patients
Authors:
Date:
2012-01-01
Journal:
European respiratory journal
Content:
Identifiers:
DOI: 10.1183/09031936.00201711
EID: 2-s2.0-84863576488
Part of ISBN: 09031936 13993003
Relationship between chest radiographic characteristics, sputum bacterial load, and treatment outcomes in patients with extensively drug-resistant tuberculosis
Authors:
J.B. te Riele , author
V. Buser , author
G. Calligaro , author
A. Esmail , author
G. Theron , author
M. Lesosky , author
K. Dheda , author
Date:
2019-02-01
Journal:
International Journal of Infectious Diseases
Content:
Identifiers:
DOI: 10.1016/j.ijid.2018.10.026
Diagnostic Performance of Xpert MTB/RIF Ultra for Tuberculosis Diagnosis in the Context of Passive and Active Case Finding Strategies in Rural Mozambique
Authors:
Saavedra, B.
Mambuque, E.
Nguenha, D.
Gomes, N.
Munguane, S.
GarcĂ­a, J.I.
Izco, S.
Acacio, S.
Murias, A.
Losada, I.
Pernas, H.
Oliveras, L.
Theron, G.
GarcĂ­a-Basteiro, A.L.
Date:
2021-01-01
Journal:
SSRN
Content:
Identifiers:
DOI: 10.2139/ssrn.3770664
EID: 2-s2.0-85110599843
Part of ISSN: 15565068
Xpert MTB/RIF test for tuberculosis
Authors:
Date:
2011-01-01
Journal:
The Lancet
Content:
Identifiers:
DOI: 10.1016/S0140-6736(11)61242-7
EID: 2-s2.0-79961239433
Part of ISBN: 01406736 1474547X
Xpert MTB/RIF Ultra is highly sensitive for the diagnosis of tuberculosis lymphadenitis in an HIV-endemic setting
Authors:
Minnies, S.
Reeve, B.W.P.
Rockman, L.
Nyawo, G.
Naidoo, C.C.
Kitchin, N.
Rautenbach, C.
Wright, C.A.
Whitelaw, A.
Schubert, P.
Warren, R.M.
Theron, G.
Date:
2021-01-01
Journal:
medRxiv
Content:
Identifiers:
DOI: 10.1101/2021.06.11.21258751
EID: 2-s2.0-85111597866
Melting the eis: Nondetection of kanamycin resistance markers by routine diagnostic tests and identification of new eis promoter variants
Authors:
Ley, S.D.
Pillay, S.
Streicher, E.M.
van der Heijden, Y.F.
Sirgel, F.
Derendinger, B.
de Kock, M.
Gagneux, S.
Warren, R.M.
Theron, G.
de Vos, M.
Date:
2021-01-01
Journal:
Antimicrobial Agents and Chemotherapy
Content:
Identifiers:
DOI: 10.1128/AAC.02502-20
EID: 2-s2.0-85108266289
Part of ISSN: 10986596 00664804
Commercial products to preserve specimens for tuberculosis diagnosis: A systematic review
Authors:
Reeve, B.W.P.
McFall, S.M.
Song, R.
Warren, R.
Steingart, K.R.
Theron, G.
Date:
2018-01-01
Journal:
International Journal of Tuberculosis and Lung Disease
Content:
Identifiers:
DOI: 10.5588/ijtld.17.0816
EID: 2-s2.0-85049170280
Part of ISBN: 18157920 10273719
An automated tuberculosis screening strategy combining X-ray-based computer-aided detection and clinical information
Authors:
Date:
2016-01-01
Journal:
Scientific Reports
Content:
Identifiers:
The diagnostic accuracy of the MTBDRplus and MTBDRsl assays for drug-resistant TB detection when performed on sputum and culture isolates
Authors:
Date:
2016-01-01
Journal:
Scientific Reports
Content:
Identifiers:
What is the cost of diagnosis and management of drug resistant tuberculosis in South Africa?
Authors:
Date:
2013-01-01
Journal:
PloS one
Content:
Identifiers:
DOI: 10.1371/journal.pone.0054587
EID: 2-s2.0-84872577328
Part of ISBN: 19326203
Data for action: Collection and use of local data to end tuberculosis
Authors:
Date:
2015-01-01
Journal:
The Lancet
Content:
Identifiers:
Point of care Xpert MTB/RIF versus smear microscopy for tuberculosis diagnosis in southern African primary care clinics: a multicentre economic evaluation
Authors:
Pooran, A.
Theron, G.
Zijenah, L.
Chanda, D.
Clowes, P.
Mwenge, L.
Mutenherwa, F.
Lecesse, P.
Metcalfe, J.
Sohn, H.
Hoelscher, M.
Pym, A.
Peter, J.
Dowdy, D.
Dheda, K.
Date:
2019-01-01
Journal:
The Lancet Global Health
Content:
Identifiers:
DOI: 10.1016/S2214-109X(19)30164-0
EID: 2-s2.0-85065469993
Part of ISBN: 2214109X
Characteristics of Xpert MTB/RIF-negative patients with pulmonary tuberculosis
Authors:
Date:
2012-01-01
Journal:
Clinical infectious diseases
Content:
Identifiers:
DOI: 10.1093/cid/cis465
EID: 2-s2.0-84863962291
Part of ISBN: 10584838 15376591
Association between interferon-$Îł$ release assay status and GeneXpert MTB/RIF positivity in patients with suspected active and latent tuberculosis infection
Authors:
Date:
2012-01-01
Journal:
South African Respiratory Journal
Content:
Identifiers:
Evaluation of the Xpert MTB/RIF assay for the diagnosis of pulmonary tuberculosis in a high HIV prevalence setting
Authors:
Date:
2011-01-01
Journal:
American journal of respiratory and critical care medicine
Content:
Identifiers:
DOI: 10.1164/rccm.201101-0056OC
EID: 2-s2.0-79960509329
Part of ISBN: 1073449X 15354970
Frequent Suboptimal Thermocycler Ramp Rate Usage Negatively Impacts GenoType MTBDRsl VER 2.0 Performance for Second-Line Drug-Resistant Tuberculosis Diagnosis.
Authors:
Derendinger B , author
de Vos M , author
Pillay S , author
Venter R , author
Metcalfe J , author
Ghebrekristos Y , author
Minnies S , author
Dolby T , author
Beylis N , author
Warren R , author
Theron G , author
Date:
2022-01-01
Journal:
The Journal of molecular diagnostics : JMD
Content:
Identifiers:
PMID: 35108607
DOI: 10.1016/j.jmoldx.2022.01.003
The role of counselling in tuberculosis diagnostic evaluation and contact tracing: scoping review and stakeholder consultation of knowledge and research gaps
Authors:
Foster, I.
Sullivan, A.
Makanda, G.
Schoeman, I.
Tisile, P.
van der Westhuizen, H.-M.
Theron, G.
Nathavitharana, R.R.
Date:
2022-01-01
Journal:
BMC Public Health
Content:
Identifiers:
DOI: 10.1186/s12889-022-12556-8
EID: 2-s2.0-85123874958
Part of ISSN: 14712458
Correlation of Xpert MTB/RIF with measures to assess Mycobacterium tuberculosis bacillary burden in high HIV burden areas of Southern Africa
Authors:
Date:
2018-01-01
Journal:
Scientific Reports
Content:
Identifiers:
The diagnostic accuracy of the GenoType® MTBDRsl assay for the detection of resistance to second-line anti-tuberculosis drugs
Authors:
Date:
2014-01-01
Journal:
The Cochrane Library
Content:
Identifiers:
DOI: 10.1002/14651858.CD010705.pub2
EID: 2-s2.0-84965185122
Part of ISBN: 1469493X
Xpert MTB/RIF results in patients with previous tuberculosis: can we distinguish true from false positive results?
Authors:
Date:
2016-01-01
Journal:
Clinical Infectious Diseases
Content:
Identifiers:
DOI: 10.1093/cid/civ1223
EID: 2-s2.0-84964903767
Part of ISBN: 15376591 10584838
Diagnostic accuracy of induced sputum LAM ELISA for tuberculosis diagnosis in sputum-scarce patients
Authors:
Date:
2012-01-01
Journal:
The International Journal of Tuberculosis and Lung Disease
Content:
Identifiers:
DOI: 10.5588/ijtld.11.0614
EID: 2-s2.0-84863568592
Part of ISBN: 10273719
Framing the Detection of Incipient Tuberculosis Infection: a qualitative study of political prioritization.
Authors:
James R , author
Theron G , author
Cobelens F , author
Engel N , author
Date:
2022-02-01
Journal:
Tropical medicine & international health : TM & IH
Content:
Identifiers:
PMID: 35156273
DOI: 10.1111/tmi.13734
Drug-resistant tuberculosis in patients with minimal symptoms: Favourable outcomes in the absence of treatment
Authors:
Loveday, M.
Ramjee, A.
Osburn, G.
Master, I.
Kabera, G.
Brust, J.C.M.
Padayatchi, N.
Warren, R.
Theron, G.
Date:
2017-01-01
Journal:
International Journal of Tuberculosis and Lung Disease
Content:
Identifiers:
DOI: 10.5588/ijtld.16.0779
EID: 2-s2.0-85018570989
Part of ISBN: 18157920 10273719
TB drug resistance in high-incidence countries
Authors:
Date:
2012-01-01
Journal:
European Respiratory Monograph Tuberculosis
Content:
Identifiers:
DOI: 10.1183/1025448x
EID: 2-s2.0-84870803676
Part of ISBN: 1025448X 20756674
Urine antigen test for diagnosis of HIV-associated tuberculosis
Authors:
Date:
2012-01-01
Journal:
The Lancet Infectious Diseases
Content:
Identifiers:
DOI: 10.1016/S1473-3099(12)70220-7
EID: 2-s2.0-84867904727
Part of ISBN: 14733099 14744457
Mycobacterial genomic DNA from used Xpert MTB/RIF cartridges can be utilised for accurate second-line genotypic drug susceptibility testing and spoligotyping
Authors:
Venter, R.
Derendinger, B.
De Vos, M.
Pillay, S.
Dolby, T.
Simpson, J.
Kitchin, N.
Ruiters, A.
Van Helden, P.D.
Warren, R.M.
Theron, G.
Date:
2017-01-01
Journal:
Scientific Reports
Content:
Identifiers:
DOI: 10.1038/s41598-017-14385-x
EID: 2-s2.0-85032839538
Part of ISBN: 20452322
Correction: Drug-Associated Adverse Events and Their Relationship with Outcomes in Patients Receiving Treatment for Extensively Drug-Resistant Tuberculosis in South Africa
Authors:
Shean K , author
Streicher E , author
Pieterson E , author
Symons G , author
van Zyl Smit R , author
Theron G , author
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2013-01-01
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The injectable contraceptive medroxyprogesterone acetate attenuates mycobacterium tuberculosis-specific host immunity through the glucocorticoid receptor
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Tomasicchio, M.
Davids, M.
Pooran, A.
Theron, G.
Smith, L.
Semple, L.
Meldau, R.
Hapgood, J.P.
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2019-01-01
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DOI: 10.1093/infdis/jiy657
EID: 2-s2.0-85064478012
Part of ISBN: 15376613 00221899
Xpert MTB/RIF Results in Patients With Previous Tuberculosis: Can We Distinguish True From False Positive Results?
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Date:
2016-01-01
Journal:
Clinical Infectious Diseases
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Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid
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King, N.
Nakhoul, M.
Zhu, H.
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Köser, C.U.
Farhat, M.
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2020-01-01
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Point-of-care technologies for the diagnosis of active tuberculosis
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Theron, G.
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2016-01-01
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The microbiome and tuberculosis: state of the art, potential applications, and defining the clinical research agenda
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Walzl, G.
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2019-01-01
Journal:
The Lancet Respiratory Medicine
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Tuberculosis screening among ambulatory people living with HIV: a systematic review and individual participant data meta-analysis
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Dhana, A.
Hamada, Y.
Kengne, A.P.
Kerkhoff, A.D.
Rangaka, M.X.
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Baddeley, A.
Miller, C.
Singh, S.
Hanifa, Y.
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Fielding, K.
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The Lancet Infectious Diseases
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Effect of new tuberculosis diagnostic technologies on community-based intensified case finding: a multicentre randomised controlled trial
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2017-01-01
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Detection of tuberculosis by automatic cough sound analysis
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Niesler, T.R.
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2018-01-01
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EID: 2-s2.0-85047351958
Part of ISBN: 13616579 09673334
How should laboratories measure mycobacterial load?
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2015-01-01
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South African Respiratory Journal
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Xpert MTB/RIF versus Sputum Smear Microscopy: Microscopy Needs a Level Playing Field
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2011-01-01
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American Journal of Respiratory and Critical Care Medicine
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Mycobacterium tuberculosis subculture results in loss of potentially clinically relevant heteroresistance
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Antimicrobial Agents and Chemotherapy
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Automated chest-radiography as a triage for Xpert testing in resource-constrained settings: A prospective study of diagnostic accuracy and costs
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2015-01-01
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Scientific Reports
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Feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing for tuberculosis in primary-care settings in Africa: a multicentre, randomised, controlled trial
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2014-01-01
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The Lancet
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Differential RD-1-specific IFN-Îł host responses to diverse Mycobacterium tuberculosis strains in HIV-uninfected persons may be explained by genotypic variation in the ESX-1 region
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Limberis, J.
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2020-01-01
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International Journal of Infectious Diseases
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Development and Clinical Evaluation of a New Multiplex PCR Assay for a Simultaneous Diagnosis of Tuberculous and Nontuberculous Mycobacteria
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Kodio, O.
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2021-01-01
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The progression of TB diagnosis in the HIV era: from microscopes to molecules and back to the bedside
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2011-01-01
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Drug-associated adverse events and their relationship with outcomes in patients receiving treatment for extensively drug-resistant tuberculosis in South Africa
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PLoS One
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The South African Tuberculosis Care Cascade: Estimated Losses and Methodological Challenges
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Do adjunct tuberculosis tests, when combined with Xpert MTB/RIF, improve accuracy and the cost of diagnosis in a resource-poor setting?
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2012-01-01
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Direct genotyping of Mycobacterium tuberculosis from Xpert <sup>®</sup> MTB/RIF remnants
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Venter, R.
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Theron, G.
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2018-01-01
Journal:
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EID: 2-s2.0-85049470853
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Comparison of Amplicor and GeneXpert MTB/RIF tests for diagnosis of tuberculous meningitis
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2014-01-01
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Blood transcriptional biomarkers for active pulmonary tuberculosis in a high-burden setting: a prospective, observational, diagnostic accuracy study
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The Lancet Respiratory Medicine
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Diagnostic accuracy and utility of FluoroType MTBDR, a new molecular assay for multidrug-resistant tuberculosis
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Bedaquiline microheteroresistance after cessation of tuberculosis treatment
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Effect on mortality of point-of-care, urine-based lipoarabinomannan testing to guide tuberculosis treatment initiation in HIV-positive hospital inpatients: A pragmatic, parallel-group, multicountry, open-label, randomised controlled trial
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Point of care diagnostics for tuberculosis
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Frequent suboptimal thermocycler ramp rate usage negatively impacts MTBDRsl performance for second-line drug resistant tuberculosis diagnosis
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Point-of-care diagnosis of tuberculosis: Past, present and future
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Tuberculosis research in South Africa over the past 30 years: From bench to bedside.
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GenoType® MTBDRsl assay for resistance to second-line anti-tuberculosis drugs
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Abstracts of the Eighth EDCTP Forum, 6-9 November 2016.
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Drug-resistant tuberculosis in 2017: at a crossroads
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ArgR--promoter interactions in Corynebacterium glutamicum arginine biosynthesis
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Development of a simple reliable radiographic scoring system to aid the diagnosis of pulmonary tuberculosis
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Extract from used Xpert MTB/RIF Ultra cartridges is useful for accurate second-line drug-resistant tuberculosis diagnosis with minimal rpoB-amplicon cross-contamination risk
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The use of an automated quantitative polymerase chain reaction (Xpert MTB/RIF) to predict the sputum smear status of tuberculosis patients
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False-Positive Xpert MTB/RIF Results in Retested Patients with Previous Tuberculosis: Frequency, Profile, and Prospective Clinical Outcomes
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Minority Mycobacterium tuberculosis Genotypic Populations as an Indicator of Subsequent Phenotypic Resistance
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Prevalence, Predictors, and Successful Treatment Outcomes of Xpert MTB/RIF-identified Rifampicin-resistant Tuberculosis in Post-conflict Eastern Democratic Republic of the Congo, 2012-2017: A Retrospective Province-Wide Cohort Study
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The diagnostic accuracy of the MTBDRplus and MTBDRsl assays for drug-resistant TB detection when performed on sputum and culture isolates
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Effect of new tuberculosis diagnostic technologies on community-based intensified case finding: a multicentre randomised controlled trial
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Accuracy and impact of Xpert MTB/RIF for the diagnosis of smear-negative or sputum-scarce tuberculosis using bronchoalveolar lavage fluid
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Outcomes, infectiousness, and transmission dynamics of patients with extensively drug-resistant tuberculosis and home-discharged patients with programmatically incurable tuberculosis: a prospective cohort study
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Data for action: collection and use of local data to end tuberculosis
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