Dr Moustapha Mbow
| Call | Career Development Fellowship (CDF) |
| Programme | EDCTP2 |
| Start Date | 2018-07-01 |
| End Date | 2021-06-30 |
| Project Code | TMA2016CDF1595 |
| Status | Active |
Title
Immune responses in rural to urban gradient: identifying geographical footprints of the immune system to improve vaccine development
Objectives
1. Assess the impact of environment differences in immune functions 2. Strengthen capacity of African scientists in conducting in-depth basic research and high dimensional data analysis for further vaccine research.
Host Organisation
| Institution | Country |
|---|---|
| Universite Cheikh Anta Diop de Dakar (UCAD) | Senegal |
| Leiden University Medical Center | Netherlands |
Participants
| Name | Institution | Country |
|---|---|---|
| Prof Maria Yazdanbakhsh | Leiden University Medical Center | Netherlands |
Study Design
1. Selection of the study population 2. Sample collection 3. Identification of cells responding to vaccine components using mass cytometry 4. Determination of immune response to vaccine components 5. Determination of transcriptional signatures by RNA sequencing
Sites
| Senegal and the Netherlands |
Students Supervised
| Type | Name | Title | University | Start Date | End Date |
|---|---|---|---|---|---|
| Master | Marouba Cissé | Cheikh Anta Diop University of Dakar | 2019 | ||
| PhD | Malick Ndoa | Cheikh Anta Diop University of Dakar | 2019 |
Current Organisation
Cheikh Anta Diop University of Dakar
Current Job Title
Assistant professor
Awards
| 2018 | CDF |
Students Supervised
| Type | Name | Title | University | Start Date | End Date |
|---|---|---|---|---|---|
| Master Thesis (Pharmacy degree) | Mbadé Ngom (Senegal) | Balance of auxiliary T cells 17 and T regulators in infection with HIV-1 | Cheikh Anta Diop University of Dakar | 2012 | 2015 |
| Master of Immunology and Infection | Mbadé Ngom (Senegal) | Investigaion of the CD40L and Tim-3 by T cells in HIV1 infection | Cheikh Anta Diop University of Dakar | 2014 | 2015 |
| Master thesis (Pharmacy degree) | Awa Diop (Senegal) | Diagnosis of latent tuberculosis by the quantiferon TB Gold® test in patients under dialysis | Cheikh Anta Diop University of Dakar | 2012 | 2014 |
| Master of Immunology | Salimata Sall Santos (Senegal) | Evaluation of the performance of HBHA test for detection of latent tuberculosis compared to Quantiferon-IT | Cheikh Anta Diop University of Dakar | 2013 | 2015 |
| Master of Immunotexicology | Babacar Diagne (Senegal) | Phenotype of T cell lymphocyte phenotype in women exposed to lead in Dakar (Senegal) | Cheikh Anta Diop University of Dakar | 2015 | 2017 |
| Master of Immunotexicology | Koudy Wane (Senegal) | Professional exposure of mechanics of the city of Dakar to benzene: evaluation of the phenotypic profile of T and B lymphocytes and NK lymphocytes | Cheikh Anta Diop University of Dakar | 2015 | 2017 |
| Master Thesis (Pharmacy degree) | Mohamed Abdoulfath (Comore) | Role of NK lymphocyte cells in the protection against HIV in serodiscordant couples | Cheikh Anta Diop University of Dakar | 2016 | 2017 |
| Master Thesis (Pharmacy degree) | Aminata Ciss (Senegal) | Review of Cancer immunotherapy | Cheikh Anta Diop University of Dakar | 2016 | 2017 |
| Master Thesis (Pharmacy degree) | Khadidiatou Diop (Senegal) | Analysis of the scientific work of the Pharmacy section of the Faculty of Medicine, Pharmacy and Ondontology between 2010 and 2015 | Cheikh Anta Diop University of Dakar | 2016 | 2017 |
| Master of Immunology and Infection | Malick Ndoa (Senegal) | Impact of the expression of CD40L and TIM-3 on IFN-γ production by T cells in pulmonary tuberculosis | Cheikh Anta Diop University of Dakar | 2016 | 2018 |
| Master of Immunology and Infection | Aissa Amar Traoré (Mali) | Investigating IFN-gamma production by NK cells in the HIV-HBV co-infection | Cheikh Anta Diop University of Dakar | 2016 | 2018 |
| Master of Immunology and Infection | Coumba Diouf (Senegal) | Optimization of intracellular staining for the detection of pro- and anti-inflammatory cytokine in spondylitis | Cheikh Anta Diop University of Dakar | 2016 | 2018 |
| Specialized Rheumatology Diploma | Coumba Diouf | Impact of HLAB27 on the clinical manifestations and evaluation criteria of spondylitis | Cheikh Anta Diop University of Dakar | 2016 | 2017 |
Education
| Institution | Degree | Year |
|---|---|---|
| Cheikh Anta Diop University of Dakar, Senegal | PharmD | 2005-12-19 |
| Cheikh Anta Diop University of Dakar, Senegal | Master of Immunology | 2009-12-30 |
| Cheikh Anta Diop University of Dakar, Senegal | University Degree of Biological Retrovirology | 2008-04-09 |
| Cheikh Anta Diop University of Dakar, Senegal | Master of Fundamental and Applied Microbiology | 2011-08-03 |
| Cheikh Anta Diop University of Dakar (Senegal) / Leiden University Medical Center (The Netherlands) / Institute of Tropical Medicine of Antwerp (Belgium), Senegal | PhD | 2014-12-19 |
| Global Health eLearning Center, United States | Certification Population, Health, and Environment | 2017-08-12 |
| Global Health eLearning Center, United States | Certification Monitoring and Evaluation | 2017-08-28 |
| Global Health eLearning Center, United States | Certification Governance and Health | 2017-09-22 |
| Central Lille, France | Advanced Project Management | 2017-12-22 |
| Coursera, United States | Certificate Epidemiology in Public Health Practice | 2017-12-10 |
Areas Of Specialisation
Human Immuno-deficiency Virus (HIV) Neglected Infectious Diseases (NID)
Grants
Grant Code:
Source of funding:
European Union
Amount:
700000
Role:
Researcher
Start Date:
2008-01-01
End Date:
2010-01-01
Grant Code:
Source of funding:
Institute of Tropical Medicine of Antwerp / Belgian Development Cooperation (DGDC)
Amount:
50000
Role:
Principal Investigator
Start Date:
2010-01-01
End Date:
2014-01-01
Grant Code:
Source of funding:
Belgian Development Cooperation (DGDC)
Amount:
70000
Role:
Researcher
Start Date:
2012-01-01
End Date:
2014-01-01
Publications
Authors:
Ateba Ngoa U, Zinsou JF, Kassa RF, Ngoune Feugap E, Honkpehedji YJ, Massinga-Loembe M, Kenguele Moundounga H, Nkoma Mouima AM, Mbenkep LH, Wammes LJ, Mbow M, Kruize Y, Mombo-Ngoma G, Bouyoukou Hounkpatin AL, Dejon Agobe JC, Saadou I, Lell B, Smits H, Kremsner PG, Yazdanbakhsh M, Adegnika AA
Date:
2014-07-29
Journal:
Springerplus
Identifiers:
Authors:
Labuda LA, de Jong SE, Meurs L, Amoah AS, Mbow M, Ateba-Ngoa U, van der Ham AJ, Knulst AC, Yazdanbakhsh M, Adegnika AA.
Date:
2014-04-14
Journal:
Plos One
Identifiers:
Authors:
Meurs L, Brienen E, Mbow M, Ochola EA, Mboup S, Karanja DM, Secor WE, Polman K, van Lieshout L
Date:
2015-07-28
Journal:
Plos Tropical Neglected Diseases
Identifiers:
Authors:
Meurs L, Mbow M, Boon N, van den Broeck F, Vereecken K, Dièye TN, Abatih E, Huyse T, Mboup S, Polman K
Date:
2013-12-26
Journal:
Plos Nelected Tropical Diseases
Identifiers:
Authors:
Meurs L, Labuda L, Amoah AS, Mbow M, Ngoa UA, Boakye DA, Mboup S, Dièye TN, Mountford AP, Turner JD, Kremsner PG, Polman K, Yazdanbakhsh M, Adegnika AA
Date:
2011-09-08
Journal:
PLoS One
Identifiers:
Authors:
Huyse T, Boon NAM, Van den Broeck F, Mbow M, Chaturvedi A, Meurs L, Volckaert FAM, Polman K
Date:
2018-02-01
Journal:
International Journal of Parasitology
Identifiers:
Authors:
Faye B, Mbow M, Cheikh Seck M, Mbengue B, Wade D, Camara M, Cissé C, Diouf SG, Ndao B, Djibo A, Sylla Niang MD, Ndiaye T, Grillo MP, Dièye A
Date:
2015-05-11
Journal:
Plos One
Identifiers:
Authors:
Meurs L, Mbow M, Vereecken K, Menten J, Mboup S, Polman K
Date:
2012-02-16
Journal:
International Journal of Parasitology
Identifiers:
Authors:
Mbow M, Santos NSS, Camara M, Ba A, Niang A, Daneau G, Wade D, Diallo AA, Toupane M, Diakhaté M, Lèye N, Diaw PA, Mboup S, Kestens L, Dieye TN
Date:
2013-09-02
Journal:
African Journal of Laboratory Medicine
Identifiers:
Authors:
Meurs L, Mbow M, Boon N, Vereecken K, Amoah AS, Labuda LA, Dièye TN, Mboup S, Yazdanbakhsh M, Polman K
Date:
2014-08-07
Journal:
Plos Negelcted Tropical Diseases
Identifiers:
Authors:
Lô G, Sow-Sall A, Diop-Ndiaye H, Babacar N, Diouf NN, Daffé SM, Ndao B, Thiam M, Mbow M, Soumboundou MB, Lemoine M, Sylla-Niang M, Ndiaye O, Boye CS, Mboup S, Touré-Kane NC
Date:
2019-03-25
Journal:
Pan African Medical Journal
Identifiers:
Authors:
Mbow M, Larkin BM, Meurs L, Wammes LJ, de Jong SE, Labuda LA, Camara M, Smits HH, Polman K, Dieye TN, Mboup S, Stadecker MJ, Yazdanbakhsh M
Date:
2012-10-19
Journal:
Journal of Infectious Diseases
Identifiers:
Authors:
Meurs L, Mbow M, Vereecken K, Menten J, Mboup S, Polman K
Date:
2012-09-27
Journal:
PLoS Neglected Tropical Diseases
Identifiers:
Authors:
Mbow M, de Jong SE, Meurs L, Mboup S, Dieye TN, Polman K, Yazdanbakhsh M
Date:
2014-12-01
Journal:
Immunology
Identifiers:
Authors:
Lô G, Sow-Sall A, Diop-Ndiaye H, Mandiouba NC, Thiam M, Diop F, Ndiaye O, Gueye SB, Seck SM, Dioura AA, Mbow M, Gaye-Diallo A, Mboup S, Touré-Kâne C
Date:
2016-03-01
Journal:
Journal of Medical Virology
Identifiers:
Authors:
Mbengue B, Fall MM, Sylla Niang M, Niang B, Varela ML, Diatta AM, Mbow M, Ndiaye K, Ndiaye Diallo R, Dieye A, Perraut R
Date:
2016-08-03
Journal:
Biomed Res Int
Identifiers:
Authors:
Diallo AB, Kollo AI, Camara M, Lo S, Ossoga GW, Mbow M, Karam F, Niang MY, Thiam A, Diawara AN, Mboup S, Diallo AG
Date:
2016-11-02
Journal:
Pan Afican Medical Journal
Identifiers:
Authors:
Turner JD, Bourke CD, Meurs L, Mbow M, Dièye TN, Mboup S, Polman K, Mountford AP
Date:
2014-04-24
Journal:
Plos Tropical Neglected Diseases
Identifiers:
Projects
Fellow:
Moustapha Mbow
Collaborators:
| Name | Country | Institution |
|---|---|---|
| Prof Maria Yazdanbakhsh | Netherlands | Leiden University Medical Center (Netherlands) |
Objectives:
1. Assess the impact of environment differences in immune functions 2. Strengthen capacity of African scientists in conducting in-depth basic research and high dimensional data analysis for further vaccine research.
Sites:
Senegal: Gropue 1. Rural (Pakh), Group 2. Semi-urban (Richard Toll), and Group 3: Urban (Dakar) settings
Netherlands: Goupe 4. Europeans
Study Design:
1. Selection of the study population 2. Sample collection
3. Identification of cells responding to vaccine components using mass cytometry
4. Determination of immune response to vaccine components
5. Determination of transcriptional signatures by RNA sequencing
Subjects:
Geographical differences of the immune response relevant to vaccines
Outcomes:
Expected outcomes: identify fooprints underlining the geograpgical differences of the immune response to vaccine components
Start Date:
2018-07-01
End Date:
2021-06-30