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Associate Professor Kwadwo Asamoah Kusi

Call Senior Fellowship (SF)
Programme EDCTP2
Start Date 2020-08-01
End Date 2024-07-31
Project Code TMA2018SF-2456
Status Active

Title

Clinical and immunopathological consequences of chronic HBV and Plasmodium falciparum co-infections

Host Organisation

Institution Country
University of Ghana Ghana

Current Organisation

NOGUCHI MEMORIAL INSTITUTE FOR MEDICAL RESEARCH(NM

Current Job Title

Senior Research Fellow

Students Supervised

Type Name Title University Start Date End Date
MPhil Bright Asare Mr University of Ghana 2020 2022
Mphil Rawdat Baba-Adam Ms University of Ghana 2020 2022
PhD Philip Selorm Segbefia Mr Kwame Nkrumah University for Science and Technology 2020 2024
PhD Diana Asema Asandem Ms University of Ghana 2019 2023

Memberships

Role Committee/board Start Date End Date
Associate Editor BMC Medicine 2021
Guest Editor Frontiers in Infectious Diseases 2022
Associate Editor Frontiers in Malaria 2022

Education

Institution Degree Year
University of Ghana, Ghana BSc Biochemistry 2000-06-30
University of Ghana, Ghana MPhil Biochemistry 2000-05-30
Leiden University Medical Centre, Netherlands PhD Medicine (Vaccine Immunology) 2012-01-22

Areas Of Specialisation

Malaria

Grants

Genomics of host-pathogen interactions underlying Streptococcus pneumoniae infection in the Ghanaian elderly population
Grant Code:
Source of funding:
PAR Foundation
Amount:
100000
Role:
Co-Principal Investigator
Start Date:
2021-01-01
End Date:
2023-01-01
Anti-pathogen and Toxicological Effects of BEEMAR®- A natural Honeybee and Enhanced Marine Plasma Product
Grant Code:
Source of funding:
Cellnutrion Health Ltd, Ireland
Amount:
232274
Role:
Principal Investigator
Start Date:
2022-01-01
End Date:
2023-01-01
Phase 1b clinical trial of a Lassa fever vaccine (LSV-002)
Grant Code:
Source of funding:
CEPI/Inovio Pharmaceuticals
Amount:
1500000
Role:
Lead Immunologist
Start Date:
2020-01-01
End Date:
2022-01-01
The role of mosquito bite on the dynamics and infectiousness-to-mosquito of asymptomatic Plasmodium falciparum carriers in Ghana
Grant Code:
Source of funding:
JEAI-IRD, France
Amount:
50000
Role:
Researcher
Start Date:
2020-01-01
End Date:
2023-01-01
CROWN CORONATION trial assessing combined effect of measles/SARS-CoV-2 live vaccinations
Grant Code:
Source of funding:
Bill and Melinda Gates Foundation
Amount:
324246
Role:
Lead Immunologist
Start Date:
2021-01-01
End Date:
2022-01-01

Publications

High infectious disease burden as a basis for the observed high frequency of asymptomatic SARS-CoV-2 infections in sub-Saharan Africa
Authors:
Kwadwo Asamoah Kusi , author
Augustina Frimpong , author
Frederica Dedo Partey , author
Helena Lamptey , author
Linda Eva Amoah , author
Michael Fokuo Ofori , author
Date:
2021-06-07
Journal:
AAS Open Research
Content:
Identifiers:
DOI: 10.12688/aasopenres.13196.2
Corrigendum: Asymptomatic Malaria Infection Is Maintained by a Balanced Pro- and Anti-inflammatory Response (Front. Microbiol., (2020), 11, (559255), 10.3389/fmicb.2020.559255)
Authors:
Frimpong, A.
Amponsah, J.
Adjokatseh, A.S.
Agyemang, D.
Bentum-Ennin, L.
Ofori, E.A.
Kyei-Baafour, E.
Akyea-Mensah, K.
Adu, B.
Mensah, G.I.
Amoah, L.E.
Kusi, K.A.
Date:
2021-01-01
Journal:
Frontiers in Microbiology
Content:
Identifiers:
DOI: 10.3389/fmicb.2021.686435
EID: 2-s2.0-85107172263
Part of ISSN: 1664302X
Measurement of ex vivo ELISpot interferon-gamma recall responses to Plasmodium falciparum AMA1 and CSP in Ghanaian adults with natural exposure to malaria
Authors:
Harini Ganeshan , author
Kwadwo A. Kusi , author
Dorothy Anum , author
Michael R. Hollingdale , author
Bjoern Peters , author
Yohan Kim , author
John K. A. Tetteh , author
Michael F. Ofori , author
Ben A. Gyan , author
Kwadwo A. Koram , author
Jun Huang , author
Maria Belmonte , author
Jo Glenna Banania , author
Daniel Dodoo , author
Eileen Villasante , author
Martha Sedegah , author
Date:
2016-12-01
Journal:
Malaria Journal
Content:
Identifiers:
DOI: 10.1186/s12936-016-1098-8
Cerebral malaria is associated with low levels of circulating endothelial progenitor cells in African children.
Authors:
Gyan B , author
Goka BQ , author
Adjei GO , author
Tetteh JK , author
Kusi KA , author
Aikins A , author
Dodoo D , author
Lesser ML , author
Sison CP , author
Das S , author
Howard ME , author
Milbank E , author
Fischer K , author
Rafii S , author
Jin D , author
Golightly LM , author
Date:
2009-04-01
Journal:
Content:
Identifiers:
PMID: 19346372
Localization and function of a Plasmodium falciparum protein (PF3D7_1459400) during erythrocyte invasion
Authors:
Amlabu, E.
Nyarko, P.B.
Opoku, G.
Ibrahim-Dey, D.
Ilani, P.
Mensah-Brown, H.
Akporh, G.A.
Akuh, O.-A.
Ayugane, E.A.
Amoh-Boateng, D.
Kusi, K.A.
Awandare, G.A.
Date:
2021-01-01
Journal:
Experimental Biology and Medicine
Content:
Identifiers:
DOI: 10.1177/1535370220961764
EID: 2-s2.0-85092149686
Part of ISSN: 15353699 15353702
Association between alpha-thalassaemia trait, Plasmodium falciparum asexual parasites and gametocyte carriage in a malaria endemic area in Southern Ghana.
Authors:
Lamptey H , author
Ofori MF , author
Adu B , author
Kusi KA , author
Dickson EK , author
Quakyi I , author
Alifrangis M , author
Date:
2019-03-01
Journal:
BMC research notes
Content:
Identifiers:
PMID: 30867026
PMC: PMC6417235
DOI: 10.1186/s13104-019-4181-8
EDiP: the Epitope Dilution Phenomenon. Lessons learnt from a malaria vaccine antigen and its applicability to polymorphic antigens.
Authors:
Kusi KA , author
Faber BW , author
Koopman G , author
Remarque EJ , author
Date:
2018-01-01
Journal:
Expert review of vaccines
Content:
Identifiers:
PMID: 29224404
DOI: 10.1080/14760584.2018.1411198
Identification of Plasmodium falciparum circumsporozoite protein-specific CD8+ T cell epitopes in a malaria exposed population
Authors:
Kwadwo A. Kusi , author
Adrian J.F. Luty , editor
Felix E. Aggor , author
Linda E. Amoah , author
Dorothy Anum , author
Yvonne Nartey , author
Daniel Amoako-Sakyi , author
Dorcas Obiri-Yeboah , author
Michael Hollingdale , author
Harini Ganeshan , author
Maria Belmonte , author
Bjoern Peters , author
Yohan Kim , author
John Tetteh , author
Eric Kyei-Baafour , author
Daniel Dodoo , author
Eileen Villasante , author
Martha Sedegah , author
Date:
2020-02-10
Journal:
PLOS ONE
Content:
Identifiers:
DOI: 10.1371/journal.pone.0228177
Serum biochemical parameters and cytokine profiles associated with natural African trypanosome infections in cattle
Authors:
Date:
2017-06-27
Journal:
Parasites & Vectors
Content:
Identifiers:
DOI: DOI 10.1186/s13071-017-2255-9
Variations in the quality of malaria-specific antibodies with transmission intensity in a seasonal malaria transmission area of Northern Ghana
Authors:
Kwadwo A. Kusi , author
Érika Martins Braga , editor
Emmanuel A. Manu , author
Theresa Manful Gwira , author
Eric Kyei-Baafour , author
Emmanuel K. Dickson , author
Jones A. Amponsah , author
Edmond J. Remarque , author
Bart W. Faber , author
Clemens H. M. Kocken , author
Daniel Dodoo , author
Ben A. Gyan , author
Gordon A. Awandare , author
Frank Atuguba , author
Abraham R. Oduro , author
Kwadwo A. Koram , author
Date:
2017-09-25
Journal:
PLOS ONE
Content:
Identifiers:
DOI: 10.1371/journal.pone.0185303
Protocol for multiplex (6-plex) measurement of anti-malarial antibodies v1
Authors:
Kwadwo Kusi , author
Date:
2017-08-01
Journal:
protocols.io
Content:
Identifiers:
DOI: 10.17504/protocols.io.jf2cjqe
Altered immunoglobulins (A and G) in Ghanaian patients with type 2 diabetes
Authors:
Henry Asare-Anane , author
Collins Paa Kwesi Botchey , author
Emmanuel Kwaku Ofori , author
Isaac Boamah , author
Sandra Crabbe , author
Kwadwo Asamoah-Kusi , author
Date:
2018-01-01
Journal:
SAGE Open Medicine
Content:
Identifiers:
DOI: 10.1177/2050312118762042
Part of ISSN: 2050-3121
IgG3 hinge region length polymorphism is associated with cerebral malaria in Ghanaian children.
Authors:
Date:
2021-11-10
Journal:
Journal of Infectious Diseases
Content:

Cerebral malaria (CM) may cause death or long-term neurological
damage in children, and several host genetic risk factors
have been reported. Malaria-specific immunoglobulin (Ig) G3
antibodies are crucial to human immune response against malaria.
The hinge region of IgG3 exhibits length polymorphism
(with long [L], medium [M], and short [S] alleles), which may
influence its functionality. We studied IgG3 hinge region length
polymorphisms in 136 Ghanaian children with malaria. Using
logistic regression models, we found that children with the
recessive MM allotype encoding medium IgG3 hinge region
length had an increased risk of CM (adjusted odds ratio, 6.67
[95% confidence interval, 1.30–34.32]; P = .004) . This has implications
for future epidemiological studies on CM.

Identifiers:
DOI: 10.1093/INFDIS/JIAB548: not informed
Immunization with different PfAMA1 alleles in sequence induces clonal imprint humoral responses that are similar to responses induced by the same alleles as a vaccine cocktail in rabbits.
Authors:
Kusi KA , author
Faber BW , author
van der Eijk M , author
Thomas AW , author
Kocken CH , author
Remarque EJ , author
Date:
2011-01-01
Journal:
Content:
Identifiers:
PMID: 21320299
PMC: PMC3050776
DOI: 10.1186/1475-2875-10-40
Feature article: Cell trace far-red is a suitable erythrocyte dye for multi-color Plasmodium falciparum invasion phenotyping assays.
Authors:
Thiam LG , author
Aniweh Y , author
Quansah EB , author
Donkor JK , author
Gwira TM , author
Kusi KA , author
Niang M , author
Awandare GA , author
Date:
2020-01-01
Journal:
Experimental biology and medicine (Maywood, N.J.)
Content:
Identifiers:
PMID: 31903776
DOI: 10.1177/1535370219897393
High plasma levels of soluble intercellular adhesion molecule (ICAM)-1 are associated with cerebral malaria.
Authors:
Adukpo S , author
Kusi KA , author
Ofori MF , author
Tetteh JK , author
Amoako-Sakyi D , author
Goka BQ , author
Adjei GO , author
Edoh DA , author
Akanmori BD , author
Gyan BA , author
Dodoo D , author
Date:
2013-01-01
Journal:
Content:
Identifiers:
PMID: 24386348
PMC: PMC3873986
DOI: 10.1371/journal.pone.0084181
Blood donor variability is a modulatory factor for P. falciparum invasion phenotyping assays
Authors:
Thiam, L.G.
Nyarko, P.B.
Kusi, K.A.
Niang, M.
Aniweh, Y.
Awandare, G.A.
Date:
2021-01-01
Journal:
Scientific Reports
Content:
Identifiers:
DOI: 10.1038/s41598-021-86438-1
EID: 2-s2.0-85103652293
Part of ISSN: 20452322
Genotypic and phenotypic diversity of Mycobacterium tuberculosis complex genotypes prevalent in West Africa
Authors:
Stephen Osei-Wusu , author
Frederick Quinn , editor
Isaac Darko Otchere , author
Portia Morgan , author
Abdul Basit Musah , author
Ishaque Mintah Siam , author
Diana Asandem , author
Theophilus Afum , author
Prince Asare , author
Adwoa Asante-Poku , author
Kwadwo Asamoah Kusi , author
Sebastien Gagneux , author
Dorothy Yeboah-Manu , author
Date:
2021-08-26
Journal:
PLOS ONE
Content:
Identifiers:
DOI: 10.1371/journal.pone.0255433
Effect of Drug Pressure on Promoting the Emergence of Antimalarial-Resistant Parasites among Pregnant Women in Ghana
Authors:
Bernard Tornyigah , author
Romain Coppée , author
Pascal Houze , author
Kwadwo A. Kusi , author
Bright Adu , author
Isabella Quakyi , author
Nathaniel Coleman , author
Atikatou Mama , author
Philippe Deloron , author
Abraham K. Anang , author
Jérôme Clain , author
Rachida Tahar , author
Michael F. Ofori , author
Nicaise Tuikue Ndam , author
Date:
2020-05-21
Journal:
Antimicrobial Agents and Chemotherapy
Content:
Identifiers:
DOI: 10.1128/AAC.02029-19
The quantity and quality of African children's IgG responses to merozoite surface antigens reflect protection against Plasmodium falciparum malaria.
Authors:
Courtin D , author
Oesterholt M , author
Huismans H , author
Kusi K , author
Milet J , author
Badaut C , author
Gaye O , author
Roeffen W , author
Remarque EJ , author
Sauerwein R , author
Garcia A , author
Luty AJ , author
Date:
2009-01-01
Journal:
Content:
Identifiers:
PMID: 19859562
PMC: PMC2763201
DOI: 10.1371/journal.pone.0007590
Patterns of inflammatory responses and parasite tolerance vary with malaria transmission intensity
Authors:
Date:
2017-04-11
Journal:
Malaria Journal
Content:
Identifiers:
DOI: DOI 10.1186/s12936-017-1796-x
Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children.
Authors:
Dodoo D , author
Aikins A , author
Kusi KA , author
Lamptey H , author
Remarque E , author
Milligan P , author
Bosomprah S , author
Chilengi R , author
Osei YD , author
Akanmori BD , author
Theisen M , author
Date:
2008-01-01
Journal:
Content:
Identifiers:
PMID: 18664257
PMC: PMC2529305
DOI: 10.1186/1475-2875-7-142
Anti-inflammatory activity and mechanism of action of ethanolic leaf extract of Morinda lucida Benth
Authors:
Ayertey, F.
Ofori-Attah, E.
Antwi, S.
Amoa-Bosompem, M.
Djameh, G.
Lartey, N.L.
Ohashi, M.
Kusi, K.A.
Appiah, A.A.
Appiah-Opong, R.
Okine, L.K.
Date:
2021-01-01
Journal:
Journal of Traditional and Complementary Medicine
Content:
Identifiers:
DOI: 10.1016/j.jtcme.2020.07.001
EID: 2-s2.0-85090837657
Part of ISSN: 22254110
Measurement of the plasma levels of antibodies against the polymorphic vaccine candidate apical membrane antigen 1 in a malaria-exposed population.
Authors:
Kusi KA , author
Dodoo D , author
Bosomprah S , author
van der Eijk M , author
Faber BW , author
Kocken CH , author
Remarque EJ , author
Date:
2012-01-01
Journal:
Content:
Identifiers:
PMID: 22299616
PMC: PMC3317819
DOI: 10.1186/1471-2334-12-32
The prevalence of submicroscopic Plasmodium falciparum gametocyte carriage and multiplicity of infection in children, pregnant women and adults in a low malaria transmission area in Southern Ghana 11 Medical and Health Sciences 1108 Medical Microbiology 11 Medical and Health Sciences 1117 Public Health and Health Services
Authors:
Lamptey, H.
Ofori, M.F.
Kusi, K.A.
Adu, B.
Owusu-Yeboa, E.
Kyei-Baafour, E.
Arku, A.T.
Bosomprah, S.
Alifrangis, M.
Quakyi, I.A.
Date:
2018-01-01
Journal:
Malaria Journal
Content:
Identifiers:
DOI: 10.1186/s12936-018-2479-y
EID: 2-s2.0-85053544314
Acquisition of IgG to ICAM-1-Binding DBLβ Domains in the Plasmodium falciparum Erythrocyte Membrane Protein 1 Antigen Family Varies between Groups A, B, and C.
Authors:
Olsen RW , author
Ecklu-Mensah G , author
Bengtsson A , author
Ofori MF , author
Kusi KA , author
Koram KA , author
Hviid L , author
Adams Y , author
Jensen ATR , author
Date:
2019-09-01
Journal:
Infection and immunity
Content:
Identifiers:
PMID: 31308082
PMC: PMC6759304
DOI: 10.1128/IAI.00224-19
Cerebral malaria is associated with low levels of circulating endothelial progenitor cells in african children
Authors:
Gyan, B.
Goka, B.Q.
Adjei, G.O.
Tetteh, J.K.A.
Kusi, K.A.
Aikins, A.
Dodoo, D.
Lesser, M.L.
Sison, C.P.
Das, S.
Howard, M.E.
Milbank, E.
Fischer, K.
Rafii, S.
Jin, D.
Golightly, L.M.
Date:
2009-01-01
Journal:
American Journal of Tropical Medicine and Hygiene
Content:
Identifiers:
EID: 2-s2.0-65349087257
Towards large-scale identification of HLA-restricted T cell epitopes from four vaccine candidate antigens in a malaria endemic community in Ghana
Authors:
Kusi, K.A.
Ofori, E.A.
Akyea-Mensah, K.
Kyei-Baafour, E.
Frimpong, A.
Ennuson, N.A.
Belmonte, M.
Ganeshan, H.
Huang, J.
Amoah, L.E.
Villasante, E.
Sedegah, M.
Date:
2022-01-01
Journal:
Vaccine
Content:
Identifiers:
DOI: 10.1016/j.vaccine.2021.12.042
EID: 2-s2.0-85121918252
Part of ISSN: 18732518 0264410X
Anti-sporozoite antibodies as alternative markers for malaria transmission intensity estimation.
Authors:
Kusi KA , author
Bosomprah S , author
Dodoo D , author
Kyei-Baafour E , author
Dickson EK , author
Mensah D , author
Angov E , author
Dutta S , author
Sedegah M , author
Koram KA , author
Date:
2014-01-01
Journal:
Content:
Identifiers:
PMID: 24635830
PMC: PMC3995447
DOI: 10.1186/1475-2875-13-103
Elevated Levels of the Endothelial Molecules ICAM-1, VEGF-A, and VEGFR2 in Microscopic Asymptomatic Malaria
Authors:
Frimpong, A.
Amponsah, J.
Agyemang, D.
Adjokatseh, A.S.
Eyiah-Ampah, S.
Ennuson, N.A.
Obiri, D.
Amoah, L.E.
Kusi, K.A.
Date:
2021-01-01
Journal:
Open Forum Infectious Diseases
Content:
Identifiers:
DOI: 10.1093/ofid/ofab302
EID: 2-s2.0-85112456605
Part of ISSN: 23288957
Strong off-target antibody reactivity to malarial antigens induced by RTS,S/AS01E vaccination is associated with protection
Authors:
Dídac Macià , author
Joseph J. Campo , author
Gemma Moncunill , author
Chenjerai Jairoce , author
Augusto J. Nhabomba , author
Maximilian Mpina , author
Hermann Sorgho , author
David Dosoo , author
Ousmane Traore , author
Kwadwo A. Kusi , author
Nana Aba Williams , author
Amit Oberai , author
Arlo Randall , author
Hector Sanz , author
Clarissa Valim , author
Kwaku P. Asante , author
Seth Owusu-Agyei , author
Halidou Tinto , author
Selidji T. Agnandji , author
Simon Kariuki , author
Ben Gyan , author
Claudia Daubenberger , author
Benjamin Mordmüller , author
Paula Petrone , author
Carlota Dobaño , author
Date:
2022-04-21
Journal:
JCI Insight
Content:
Identifiers:
DOI: 10.1172/jci.insight.158030
T-cell responses against Malaria: Effect of parasite antigen diversity and relevance for vaccine development
Authors:
Omarine Nfor Nlinwe , author
Kwadwo Asamoah Kusi , author
Bright Adu , author
Martha Sedegah , author
Date:
2018-04-01
Journal:
Vaccine
Content:
Identifiers:
DOI: 10.1016/j.vaccine.2018.03.023
Part of ISSN: 0264-410X
The COVID-19 pandemic in the African continent
Authors:
Godfrey Bwire , author
Alex Riolexus Ario , author
Patricia Eyu , author
Felix Ocom , author
Joseph F. Wamala , author
Kwadwo A. Kusi , author
Latif Ndeketa , author
Kondwani C. Jambo , author
Rhoda K. Wanyenze , author
Ambrose O. Talisuna , author
Date:
2022-12-01
Journal:
BMC Medicine
Content:
Identifiers:
DOI: 10.1186/s12916-022-02367-4
A STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children
Authors:
Date:
2016-04-07
Journal:
Content:
Identifiers:
DOI: doi:10.4137/GEG.S38307
Cryptolepine and Nibima inhibit hepatitis B virus replication
Authors:
Domfeh, S.A.
Narkwa, P.W.
Quaye, O.
Kusi, K.A.
Rivera, O.
Danaah, M.M.
Musah, B.A.N.
Awandare, G.A.
Mensah, K.B.
Mutocheluh, M.
Date:
2021-01-01
Journal:
Scientific African
Content:
Identifiers:
DOI: 10.1016/j.sciaf.2021.e00942
EID: 2-s2.0-85123024682
Part of ISSN: 24682276
Comparative analysis of the ex vivo IFN-gamma responses to CD8+ T cell epitopes within allelic forms of PfAMA1 in subjects with natural exposure to malaria
Authors:
Omarine N. Nlinwe , author
Luzia Helena Carvalho , editor
Ebenezer A. Ofori , author
Kwadwo Akyea-Mensah , author
Eric Kyei-Baafour , author
Harini Ganeshan , author
Maria Belmonte , author
Bjoern Peters , author
Eileen Villasante , author
Martha Sedegah , author
Kwadwo Asamoah Kusi , author
Date:
2021-09-10
Journal:
PLOS ONE
Content:
Identifiers:
DOI: 10.1371/journal.pone.0257219
Characterization of anti-EBA175RIII-V in asymptomatic adults and children living in communities in the Greater Accra Region of Ghana with varying malaria transmission intensities
Authors:
Amoah, L.E.
Abagna, H.B.
Akyea-Mensah, K.
Lo, A.C.
Kusi, K.A.
Gyan, B.A.
Date:
2018-01-01
Journal:
BMC immunology
Content:
Identifiers:
DOI: 10.1186/s12865-018-0271-y
EID: 2-s2.0-85056693816
Comparison of the impact of allelic polymorphisms in PfAMA1 on the induction of T Cell responses in high and low malaria endemic communities in Ghana
Authors:
Ebenezer A. Ofori , author
John K. A. Tetteh , author
Augustina Frimpong , author
Harini Ganeshan , author
Maria Belmonte , author
Bjoern Peters , author
Eileen Villasante , author
Martha Sedegah , author
Michael F. Ofori , author
Kwadwo A. Kusi , author
Date:
2021-12-01
Journal:
Malaria Journal
Content:
Identifiers:
DOI: 10.1186/s12936-021-03900-1
Antigenicity and immune correlate assessment of seven Plasmodium falciparum antigens in a longitudinal infant cohort from northern Ghana
Authors:
Kwadwo Asamoah Kusi , author
Joao Aguiar , author
Selassie Kumordjie , author
Felix Aggor , author
Jessica Bolton , author
Andrea Renner , author
Eric Kyei-Baafour , author
Naiki Puplampu , author
Maria Belmonte , author
Daniel Dodoo , author
Ben Adu Gyan , author
Michael Fokuo Ofori , author
Abraham Rex Oduro , author
Frank Atuguba , author
Kwadwo Ansah Koram , author
Nehkonti Adams , author
Andrew Letizia , author
Eileen Villasante , author
Martha Sedegah , author
Date:
2019-12-01
Journal:
Scientific Reports
Content:
Identifiers:
DOI: 10.1038/s41598-019-45092-4
Intermittent preventive treatment in pregnancy with sulfadoxine–pyrimethamine and parasite resistance: cross-sectional surveys from antenatal care visit and delivery in rural Ghana
Authors:
Mama, A.
Ahiabor, C.
Tornyigah, B.
Frempong, N.A.
Kusi, K.A.
Adu, B.
Courtin, D.
Houzé, S.
Deloron, P.
Ofori, M.F.
Anang, A.K.
Ariey, F.
Ndam, N.T.
Date:
2022-01-01
Journal:
Malaria Journal
Content:
Identifiers:
DOI: 10.1186/s12936-022-04124-7
EID: 2-s2.0-85127296971
Part of ISSN: 14752875
Comparison of the impact of allelic polymorphisms in PfAMA1 on the induction of T Cell responses in high and low malaria endemic communities in Ghana
Authors:
Ebenezer Addo Ofori , author
John Kweku A Tetteh , author
Augustina Frimpong , author
Harini Ganeshan , author
Maria Belmonte , author
Bjoern Peters , author
Eileen Villasante , author
Martha Sedegah , author
Michael Fokuo Ofori , author
Kwadwo Asamoah Kusi , author
Date:
2021-07-02
Journal:
Content:
Identifiers:
DOI: 10.21203/rs.3.rs-605788/v1
Asymptomatic Malaria Infection Is Maintained by a Balanced Pro- and Anti-inflammatory Response
Authors:
Frimpong, A.
Amponsah, J.
Adjokatseh, A.S.
Agyemang, D.
Bentum-Ennin, L.
Ofori, E.A.
Kyei-Baafour, E.
Akyea-Mensah, K.
Adu, B.
Mensah, G.I.
Amoah, L.E.
Kusi, K.A.
Date:
2020-01-01
Journal:
Frontiers in Microbiology
Content:
Identifiers:
DOI: 10.3389/fmicb.2020.559255
EID: 2-s2.0-85097055803
Part of ISSN: 1664302X
Measuring naturally acquired ex vivo IFN-γ responses to Plasmodium falciparum cell-traversal protein for ookinetes and sporozoites (CelTOS) in Ghanaian adults.
Authors:
Anum D , author
Kusi KA , author
Ganeshan H , author
Hollingdale MR , author
Ofori MF , author
Koram KA , author
Gyan BA , author
Adu-Amankwah S , author
Badji E , author
Huang J , author
Belmonte M , author
Banania GJ , author
Kwofie TB , author
Villasante E , author
Dodoo D , author
Sedegah M , author
Date:
2015-01-01
Journal:
Content:
Identifiers:
PMID: 25604473
PMC: PMC4308902
DOI: 10.1186/s12936-014-0539-5
Towards large-scale identification of HLA-restricted T cell epitopes from four vaccine candidate antigens in a malaria endemic community in Ghana
Authors:
Kwadwo A Kusi
Date:
2021-12-27
Journal:
Vaccine
Content:

Sterile protection against clinical malaria has been achieved in animal models and experimental
human challenge studies involving immunization with radiation attenuated Plasmodium falciparum
sporozoite vaccines as well as by live sporozoites under chloroquine prophylaxis. Parasite-specific
IFN-c and granzyme B-secreting CD8 + T cells have been identified as key mediators of protection.
Although the exact parasite targets of protective CD8 + T cell responses are not fully defined,
responses against a handful of vaccine candidate antigens have been associated with protection.
Identifying the T cell targets in these antigens will facilitate the development of simpler, costeffective,
and efficacious next generation multi-epitope vaccines. The aim of this study was to identify
immunodominant portions of four malaria vaccine candidate antigens using peripheral blood
mononuclear cells (PBMCs) from adults with life-long exposure to malaria parasites. Cryopreserved
PBMCs from 291 HLA-typed subjects were stimulated with pools of overlapping 15mer peptides spanning
the entire sequences of P. falciparum circumsporozoite protein (CSP, 9 pools), apical membrane
antigen 1 (AMA1, 12 pools), thrombospondin related anonymous protein (TRAP, 6 pools) and cell
traversal for ookinetes and sporozoites (CelTOS, 4 pools) in FluoroSpot assays. 125 of 291 subjects
made IFN-c responses to 30 of the 31 peptide pools tested and 22 of 291 made granzyme B
responses, with 20 making dual responses. The most frequent responses were to the CSP Cterminal
region and the least frequent responses were to TRAP and CelTOS. There was no association
between FluoroSpot responses and active malaria infection, detected by either microscopy, RDT, or
PCR.
In conclusion, CSP and AMA1 have relatively higher numbers of epitopes that trigger IFN-c and
granzyme B-secreting T cells in adults with life-long malaria parasite exposure compared to the other
two antigens tested, and highlights the continued relevance of these two antigens as vaccine
candidates.

Identifiers:
Not Informed: not informed
High infectious disease burden as a basis for the observed high frequency of asymptomatic SARS-CoV-2 infections in sub-Saharan Africa [version 3; peer review: 2 approved]
Authors:
Kwadwo Asamoah Kusi , author
Augustina Frimpong , author
Frederica Dedo Partey , author
Helena Lamptey , author
Linda Eva Amoah , author
Michael Fokuo Ofori , author
Date:
2021-10-18
Journal:
Content:
Identifiers:
DOI: 10.12688/aasopenres.13196.3
Part of ISSN: 2515-9321
Impact of an Irrigation Dam on the Transmission and Diversity of Plasmodium falciparum in a Seasonal Malaria Transmission Area of Northern Ghana.
Authors:
Kyei-Baafour E , author
Tornyigah B , author
Buade B , author
Bimi L , author
Oduro AR , author
Koram KA , author
Gyan BA , author
Kusi KA , author
Date:
2020-03-01
Journal:
Journal of tropical medicine
Content:
Identifiers:
PMID: 32308690
PMC: PMC7155757
DOI: 10.1155/2020/1386587
Blood donor variability is a modulatory factor for P. falciparum invasion phenotyping assays
Authors:
Laty G. Thiam , author
Prince B. Nyarko , author
Kwadwo A. Kusi , author
Makhtar Niang , author
Yaw Aniweh , author
Gordon A. Awandare , author
Date:
2020-05-27
Journal:
Content:
Identifiers:
DOI: 10.1101/2020.05.27.116939
Phenotypic Evidence of T Cell Exhaustion and Senescence During Symptomatic Plasmodium falciparum Malaria
Authors:
Date:
2019-06-18
Journal:
Frontiers in Immunology
Content:
Identifiers:
DOI: 10.3389/fimmu.2019.01345
Part of ISSN: 1664-3224
High uptake of Intermittent Preventive Treatment of malaria in pregnancy is associated with improved birth weight among pregnant women in Ghana
Authors:
Isabella Quakyi , author
Bernard Tornyigah , author
Pascal Houze , author
Kwadwo A. Kusi , author
Nathaniel Coleman , author
Guillaume Escriou , author
Amos Laar , author
Michel Cot , author
Julius Fobil , author
Gloria Quansah Asare , author
Philippe Deloron , author
Abraham K. Anang , author
Gilles Cottrell , author
Michael F. Ofori , author
Nicaise Tuikue Ndam , author
Date:
2019-12-01
Journal:
Scientific Reports
Content:
Identifiers:
DOI: 10.1038/s41598-019-55046-5
Seroprevalence of Antibodies against Plasmodium falciparum Sporozoite Antigens as Predictive Disease Transmission Markers in an Area of Ghana with Seasonal Malaria Transmission
Authors:
Kwadwo A. Kusi , author
Georges Snounou , editor
Samuel Bosomprah , author
Eric Kyei-Baafour , author
Emmanuel K. Dickson , author
Bernard Tornyigah , author
Evelina Angov , author
Sheetij Dutta , author
Daniel Dodoo , author
Martha Sedegah , author
Kwadwo A. Koram , author
Date:
2016-11-22
Journal:
PLOS ONE
Content:
Identifiers:
DOI: 10.1371/journal.pone.0167175
Humoral immune response to mixed PfAMA1 alleles; multivalent PfAMA1 vaccines induce broad specificity.
Authors:
Kusi KA , author
Faber BW , author
Thomas AW , author
Remarque EJ , author
Date:
2009-01-01
Journal:
Content:
Identifiers:
PMID: 19956619
PMC: PMC2779588
DOI: 10.1371/journal.pone.0008110
Safety and immunogenicity of multi-antigen AMA1-based vaccines formulated with CoVaccine HT™ and Montanide ISA 51 in rhesus macaques.
Authors:
Kusi KA , author
Remarque EJ , author
Riasat V , author
Walraven V , author
Thomas AW , author
Faber BW , author
Kocken CH , author
Date:
2011-01-01
Journal:
Content:
Identifiers:
PMID: 21726452
PMC: PMC3142537
DOI: 10.1186/1475-2875-10-182
Characterization of T cell activation and regulation in children with asymptomatic Plasmodium falciparum infection
Authors:
Frimpong, A.
Kusi, K.A.
Tornyigah, B.
Ofori, M.F.
Ndifon, W.
Date:
2018-01-01
Journal:
Malaria Journal
Content:
Identifiers:
DOI: 10.1186/s12936-018-2410-6
EID: 2-s2.0-85050006495
In vitro Anti-Plasmodial Activity of Aqueous and Ethanolic Extracts of Moringa oleifera and Phyllanthus amarus
Authors:
Date:
2015-01-01
Journal:
Content:
Identifiers:
DOI: 10.3923/ijbc.2015.198.206
Analysis of Plasmodium falciparum Rh2b deletion polymorphism across different transmission areas.
Authors:
Aniweh Y , author
Suurbaar J , author
Morang'a CM , author
Nyarko PB , author
Wright KE , author
Kusi KA , author
Ansah F , author
Kyei-Baafour E , author
Quansah E , author
Asante J , author
Thiam LG , author
Higgins MK , author
Awandare GA , author
Date:
2020-01-01
Journal:
Scientific reports
Content:
Identifiers:
PMID: 32001728
PMC: PMC6992740
DOI: 10.1038/s41598-020-58300-3
Novel Strategies for Malaria Vaccine Design
Authors:
Augustina Frimpong , author
Kwadwo Asamoah Kusi , author
Michael Fokuo Ofori , author
Wilfred Ndifon , author
Date:
2018-11-01
Journal:
Frontiers in Immunology
Content:
Identifiers:
DOI: 10.3389/fimmu.2018.02769
Part of ISSN: 1664-3224
Cryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling
Authors:
Domfeh, S.A.
Narkwa, P.W.
Quaye, O.
Kusi, K.A.
Awandare, G.A.
Ansah, C.
Salam, A.
Mutocheluh, M.
Date:
2021-01-01
Journal:
BMC Complementary Medicine and Therapies
Content:
Identifiers:
DOI: 10.1186/s12906-021-03326-x
EID: 2-s2.0-85107062790
Part of ISSN: 26627671
Histopathological lesions and exposure to Plasmodium falciparum infections in the placenta increases the risk of preeclampsia among pregnant women
Authors:
Obiri, D.
Erskine, I.J.
Oduro, D.
Kusi, K.A.
Amponsah, J.
Gyan, B.A.
Adu-Bonsaffoh, K.
Ofori, M.F.
Date:
2020-01-01
Journal:
Scientific Reports
Content:
Identifiers:
DOI: 10.1038/s41598-020-64736-4
EID: 2-s2.0-85084963112
Part of ISSN: 20452322
Generation of humoral immune responses to multi-allele PfAMA1 vaccines; effect of adjuvant and number of component alleles on the breadth of response.
Authors:
Kusi KA , author
Faber BW , author
Riasat V , author
Thomas AW , author
Kocken CH , author
Remarque EJ , author
Date:
2010-01-01
Journal:
Content:
Identifiers:
PMID: 21082025
PMC: PMC2972715
DOI: 10.1371/journal.pone.0015391
High infectious disease burden as a basis for the observed high frequency of asymptomatic SARS-CoV-2 infections in sub-Saharan Africa
Authors:
Kwadwo Asamoah Kusi , author
Augustina Frimpong , author
Frederica Dedo Partey , author
Helena Lamptey , author
Linda Eva Amoah , author
Michael Fokuo Ofori , author
Date:
2021-01-13
Journal:
AAS Open Research
Content:
Identifiers:
DOI: 10.12688/aasopenres.13196.1
Hepatitis B infection outcome is associated with novel human leukocyte antigen variants in Ghanaian cohort.
Authors:
Tandoh KZ , author
Kusi KA , author
Archampong TN , author
Boamah I , author
Quaye O , author
Date:
2020-04-01
Journal:
Experimental biology and medicine (Maywood, N.J.)
Content:
Identifiers:
PMID: 32349537
DOI: 10.1177/1535370220921118
Activity of Herbal Medicines on Plasmodium falciparum Gametocytes: Implications for Malaria Transmission in Ghana.
Authors:
Amoah LE , author
Kakaney C , author
Kwansa-Bentum B , author
Kusi KA , author
Date:
2015-01-01
Journal:
Content:
Identifiers:
PMID: 26562778
PMC: PMC4642932
DOI: 10.1371/journal.pone.0142587
Levels of soluble CD163 and severity of malaria in children in Ghana.
Authors:
Kusi KA , author
Gyan BA , author
Goka BQ , author
Dodoo D , author
Obeng-Adjei G , author
Troye-Blomberg M , author
Akanmori BD , author
Adjimani JP , author
Date:
2008-09-01
Journal:
Content:
Identifiers:
PMID: 18632918
PMC: PMC2546665
DOI: 10.1128/CVI.00506-07
Suitability of IgG responses to multiple Plasmodium falciparum antigens as markers of transmission intensity and pattern
Authors:
Eric Kyei-Baafour , author
Takafumi Tsuboi , editor
Mavis Oppong , author
Kwadwo Asamoah Kusi , author
Abena Fremaah Frempong , author
Belinda Aculley , author
Fareed K. N. Arthur , author
Regis Wendpayangde Tiendrebeogo , author
Susheel K. Singh , author
Michael Theisen , author
Margaret Kweku , author
Bright Adu , author
Lars Hviid , author
Michael Fokuo Ofori , author
Date:
2021-04-22
Journal:
PLOS ONE
Content:
Identifiers:
DOI: 10.1371/journal.pone.0249936

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