EDCTP Alumni Network

Fostering excellence and collaboration in the next generation of researchers

All Profiles

Dr Benjamin Chimukangara

Call Career Development Fellowship (CDF)
Programme EDCTP2
Start Date 2020-09-01
End Date 2023-08-31
Project Code TMA2019CDF-2728
Status Active

Title

Monitoring of HIV drug resistance in South Africa and innovative approaches to HIV drug resistance testing (HIVDR-MIT)

Host Organisation

Institution Country
Centre for the Aids Programme of Research in South Africa (CAPRISA) South Africa

Current Organisation

CAPRISA and U.S. NIH

Current Job Title

Postdoctoral Fellow

Students Supervised

Type Name Title University Start Date End Date
Masters Sontaga Manyana Innovative and affordable HIV-1 drug resistance testing for resource limited settings University of KwaZulu-Natal 2021 2022
PhD Lilishia Gounder Monitoring and analysis of HIV-1 drug resistance in KwaZulu-Natal, South Africa University of KwaZulu-Natal 2021 2023
PhD Tendai Washaya Investigating pan-resistant HIV-1 among highly treatment experienced patients in Zimbabwe University of Zimbabwe 2021 2023

Memberships

Role Committee/board Start Date End Date
Committee member Zimbabwe Young Academy of Sciences (ZIMYAS) 2020 2022

Education

Institution Degree Year
University of KwaZulu-Natal, South Africa PhD Virology 2019-04-04
University of Zimbabwe, Zimbabwe MPhil Molecular Virology 2015-06-05
Midlands State University, Zimbabwe BSc Hon Biological Sciences 2010-06-15

Areas Of Specialisation

Human Immuno-deficiency Virus (HIV) Lower Respiratory Tract Infections (LRTIs)

Publications

A Simple Phosphate-Buffered-Saline-Based Extraction Method Improves Specificity of HIV Viral Load Monitoring Using Dried Blood Spots.
Authors:
Makadzange AT , author
Boyd FK , author
Chimukangara B , author
Masimirembwa C , author
Katzenstein D , author
Ndhlovu CE , author
Date:
2017-05-01
Journal:
Journal of clinical microbiology
Content:
Identifiers:
PMID: 28468852
PMC: PMC5483919
DOI: 10.1128/jcm.00176-17
Persistent Hepatitis B Viraemia with Polymerase Mutations among HIV/HBV Co-Infected Patients on HBV-Active ART in KwaZulu-Natal, South Africa
Authors:
Nokukhanya Msomi , author
Raveen Parboosing , author
Eduan Wilkinson , author
Jennifer Giandhari , author
Kerusha Govender , author
Benjamin Chimukangara , author
Koleka P. Mlisana , author
Date:
2022-04-01
Journal:
Viruses
Content:
Identifiers:
DOI: 10.3390/v14040788
Drug resistance mutations from whole blood proviral DNA among patients on antiretroviral drugs in Zimbabwe.
Authors:
Chimukangara B , author
Gwanzura L , author
Mitchell R , author
Katzenstein D , author
Masimirembwa C , author
Date:
2014-01-01
Journal:
Current HIV research
Content:
Identifiers:
PMID: 25323793
DOI: 10.2174/1570162x12666141017100733
Recurrent tuberculosis among HIV-coinfected patients: a case series from KwaZulu-Natal.
Authors:
Naidoo K , author
Dookie N , author
Naidoo K , author
Yende-Zuma N , author
Chimukangara B , author
Bhushan A , author
Govender D , author
Gengiah S , author
Padayatchi N , author
Date:
2018-09-01
Journal:
Infection and drug resistance
Content:
Identifiers:
PMID: 30233220
PMC: PMC6130302
DOI: 10.2147/idr.s150644
HIV drug resistance testing among patients failing second line antiretroviral therapy. Comparison of in-house and commercial sequencing.
Authors:
Chimukangara B , author
Varyani B , author
Shamu T , author
Mutsvangwa J , author
Manasa J , author
White E , author
Chimbetete C , author
Luethy R , author
Katzenstein D , author
Date:
2016-11-01
Journal:
Journal of virological methods
Content:
Identifiers:
PMID: 27894862
PMC: PMC5393912
DOI: 10.1016/j.jviromet.2016.11.010
Whole Genome Sequencing of SARS-CoV-2: Adapting Illumina Protocols for Quick and Accurate Outbreak Investigation During a Pandemic
Authors:
Pillay S , author
Giandhari J , author
Tegally H , author
Wilkinson E , author
Chimukangara B , author
Lessells R , author
Moosa Y , author
Gazy I , author
Fish M , author
Singh L , author
Khanyile KS , author
Fonseca V , author
Giovanetti M , author
de Oliveira T , author
Date:
2020-06-01
Journal:
Content:
Identifiers:
PPR: PPR174332
DOI: 10.1101/2020.06.10.144212
HIV-1 drug resistance in adults and adolescents on protease inhibitor-based antiretroviral therapy in KwaZulu-Natal Province, South Africa
Authors:
Benjamin Chimukangara , author
Richard J. Lessells , author
Benn Sartorius , author
Lilishia Gounder , author
Sontaga Manyana , author
Melendhran Pillay , author
Lavanya Singh , author
Jennifer Giandhari , author
Kerusha Govender , author
Reshmi Samuel , author
Nokukhanya Msomi , author
Kogieleum Naidoo , author
Tulio de Oliveira , author
Pravi Moodley , author
Raveen Parboosing , author
Date:
2021-11-01
Journal:
Journal of Global Antimicrobial Resistance
Content:
Identifiers:
DOI: 10.1016/j.jgar.2021.10.023
Early transmission of SARS-CoV-2 in South Africa: An epidemiological and phylogenetic report.
Authors:
Giandhari J , author
Pillay S , author
Wilkinson E , author
Tegally H , author
Sinayskiy I , author
Schuld M , author
Lourenço J , author
Chimukangara B , author
Lessells R , author
Moosa Y , author
Gazy I , author
Fish M , author
Singh L , author
de Oliveira T , author
Date:
2020-11-01
Journal:
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Content:
Identifiers:
PMID: 33189939
PMC: PMC7658561
DOI: 10.1016/j.ijid.2020.11.128
Primary HIV-1 Drug Resistant Minority Variants.
Authors:
Chimukangara B , author
Samuel R , author
Naidoo K , author
de Oliveira T , author
Date:
2017-04-01
Journal:
AIDS reviews
Content:
Identifiers:
PMID: 28182621
Transmission dynamics of SARS-CoV-2 within-host diversity in two major hospital outbreaks in South Africa.
Authors:
San JE , author
Ngcapu S , author
Kanzi AM , author
Tegally H , author
Fonseca V , author
Giandhari J , author
Wilkinson E , author
Nelson CW , author
Smidt W , author
Kiran AM , author
Chimukangara B , author
Pillay S , author
Singh L , author
Fish M , author
de Oliveira T , author
Date:
2021-01-01
Journal:
Virus evolution
Content:
Identifiers:
PMID: 34035952
PMC: PMC8135343
DOI: 10.1093/ve/veab041
HIV-1 Drug Resistance Genotyping in Resource Limited Settings: Current and Future Perspectives in Sequencing Technologies.
Authors:
Manyana S , author
Gounder L , author
Pillay M , author
Manasa J , author
Naidoo K , author
Chimukangara B , author
Date:
2021-06-01
Journal:
Viruses
Content:
Identifiers:
PMID: 34208165
PMC: PMC8230827
DOI: 10.3390/v13061125
Acquired HIV drug resistance and virologic monitoring in a HIV hyper-endemic setting in KwaZulu-Natal Province, South Africa
Authors:
Benjamin Chimukangara , Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa
Date:
2021-10-16
Journal:
AIDS Research and Therapy
Content:
Identifiers:
34656129: not informed
Early transmission of SARS-CoV-2 in South Africa: An epidemiological and phylogenetic report
Authors:
Giandhari J , author
Pillay S , author
Wilkinson E , author
Tegally H , author
Sinayskiy I , author
Schuld M , author
Lourenco J , author
Chimukangara B , author
Lessells R , author
Moosa Y , author
Gazy I , author
Fish M , author
Singh L , author
de Oliveira T , author
Date:
2020-05-01
Journal:
Content:
Identifiers:
PPR: PPR169301
DOI: 10.1101/2020.05.29.20116376
Acquired HIV drug resistance and virologic monitoring in a HIV hyper-endemic setting in KwaZulu-Natal Province, South Africa
Authors:
Benjamin Chimukangara
Date:
2021-10-17
Journal:
AIDS Research and Therapy
Content:
Identifiers:
Not Informed: not informed
Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase.
Authors:
Siedner MJ , author
Moorhouse MA , author
Simmons B , author
de Oliveira T , author
Lessells R , author
Giandhari J , author
Kemp SA , author
Chimukangara B , author
Akpomiemie G , author
Serenata CM , author
Venter WDF , author
Hill A , author
Gupta RK , author
Date:
2020-12-01
Journal:
Nature communications
Content:
Identifiers:
PMID: 33262331
PMC: PMC7708638
DOI: 10.1038/s41467-020-19801-x
Use of Proviral DNA to Investigate Virus Resistance Mutations in HIV-infected Zimbabweans.
Authors:
Musingwini TV , author
Zhou DT , author
Zhou DT , author
Mhandire D , author
Duri K , author
Gomo E , author
Oktedalen O , author
Chimukangara B , author
Shamu T , author
Shawarira-Bote S , author
Dandara C , author
Stray-Pedersen B , author
Date:
2017-04-01
Journal:
The open microbiology journal
Content:
Identifiers:
PMID: 28553415
PMC: PMC5427698
DOI: 10.2174/1874285801711010045
Whole Genome Sequencing of SARS-CoV-2: Adapting Illumina Protocols for Quick and Accurate Outbreak Investigation during a Pandemic.
Authors:
Pillay S , author
Giandhari J , author
Tegally H , author
Wilkinson E , author
Chimukangara B , author
Lessells R , author
Moosa Y , author
Mattison S , author
Gazy I , author
Fish M , author
Singh L , author
Khanyile KS , author
San JE , author
de Oliveira T , author
Date:
2020-08-01
Journal:
Genes
Content:
Identifiers:
PMID: 32824573
PMC: PMC7464704
DOI: 10.3390/genes11080949
Trends in Pretreatment HIV-1 Drug Resistance in Antiretroviral Therapy-naive Adults in South Africa, 2000-2016: A Pooled Sequence Analysis.
Authors:
Chimukangara B , author
Lessells RJ , author
Rhee SY , author
Giandhari J , author
Kharsany ABM , author
Naidoo K , author
Lewis L , author
Cawood C , author
Khanyile D , author
Ayalew KA , author
Diallo K , author
Samuel R , author
Hunt G , author
de Oliveira T , author
Date:
2019-03-01
Journal:
EClinicalMedicine
Content:
Identifiers:
PMID: 31143879
PMC: PMC6510720
DOI: 10.1016/j.eclinm.2019.03.006
Community Based Antiretroviral Treatment in Rural Zimbabwe.
Authors:
Chimukangara B , author
Manasa J , author
Mitchell R , author
Nyabadza G , author
Katzenstein D , author
Masimirembwa C , author
Date:
2017-10-01
Journal:
AIDS research and human retroviruses
Content:
Identifiers:
PMID: 28899102
DOI: 10.1089/aid.2017.0029
Moderate-to-High Levels of Pretreatment HIV Drug Resistance in KwaZulu-Natal Province, South Africa.
Authors:
Chimukangara B , author
Kharsany ABM , author
Lessells RJ , author
Naidoo K , author
Rhee SY , author
Manasa J , author
Gräf T , author
Lewis L , author
Cawood C , author
Khanyile D , author
Diallo K , author
Ayalew KA , author
Shafer RW , author
de Oliveira T , author
Date:
2019-01-01
Journal:
AIDS research and human retroviruses
Content:
Identifiers:
PMID: 30430843
PMC: PMC6360398
DOI: 10.1089/aid.2018.0202
HIV-1 integrase strand transfer inhibitors: a review of current drugs, recent advances and drug resistance
Authors:
Nokuzola Mbhele , author
Benjamin Chimukangara , author
Michelle Gordon , author
Date:
2021-05-01
Journal:
International Journal of Antimicrobial Agents
Content:
Identifiers:
DOI: 10.1016/j.ijantimicag.2021.106343
Clinical, Virologic, Immunologic Outcomes and Emerging HIV Drug Resistance Patterns in Children and Adolescents in Public ART Care in Zimbabwe.
Authors:
Makadzange AT , author
Higgins-Biddle M , author
Chimukangara B , author
Birri R , author
Gordon M , author
Mahlanza T , author
McHugh G , author
van Dijk JH , author
Bwakura-Dangarembizi M , author
Ndung'u T , author
Ndhlovu CE , author
Date:
2015-12-01
Journal:
PloS one
Content:
Identifiers:
PMID: 26658814
PMC: PMC4678607
DOI: 10.1371/journal.pone.0144057
High Resolution analysis of Transmission Dynamics of Sars-Cov-2 in Two Major Hospital Outbreaks in South Africa Leveraging Intrahost Diversity
Authors:
James SE , author
Ngcapu S , author
Kanzi AM , author
Tegally H , author
Fonseca V , author
Giandhari J , author
Wilkinson E , author
Chimukangara B , author
Pillay S , author
Singh L , author
Fish M , author
Gazy I , author
Khanyile K , author
de Oliveira T , author
Date:
2020-11-01
Journal:
Content:
Identifiers:
PPR: PPR238338
DOI: 10.1101/2020.11.15.20231993
Impact of pretreatment low-abundance HIV-1 drug-resistant variants on virological failure among HIV-1/TB-co-infected individuals.
Authors:
Chimukangara B , author
Giandhari J , author
Lessells R , author
Yende-Zuma N , author
Sartorius B , author
Samuel R , author
Khanyile KS , author
Stray-Pedersen B , author
Moodley P , author
Metzner KJ , author
Padayatchi N , author
De Oliveira T , author
Date:
2020-11-01
Journal:
The Journal of antimicrobial chemotherapy
Content:
Identifiers:
PMID: 32772079
PMC: PMC7566390
DOI: 10.1093/jac/dkaa343
Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase
Authors:
Siedner M , author
Moorhouse M , author
Simmons B , author
Oliveira Td , author
Lessells R , author
Giandhari J , author
Kemp S , author
Chimukangara B , author
Akpomiemie G , author
Serenata C , author
Venter W , author
Hill A , author
Gupta R , author
Date:
2020-08-01
Journal:
Content:
Identifiers:
PPR: PPR197011
DOI: 10.21203/rs.3.rs-45647/v1
Next Generation Sequencing and Bioinformatics Analysis of Family Genetic Inheritance.
Authors:
Kanzi AM , author
San JE , author
Chimukangara B , author
Wilkinson E , author
Fish M , author
Ramsuran V , author
de Oliveira T , author
Date:
2020-10-01
Journal:
Frontiers in genetics
Content:
Identifiers:
PMID: 33193618
PMC: PMC7649788
DOI: 10.3389/fgene.2020.544162

Send a Message