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Dr Christina Thobakgale

Call Senior Fellowship (SF)
Programme EDCTP2
Start Date 2020-02-01
End Date 2025-01-31
Project Code TMA2018SF-2447
Status Active

Title

Innate Immunological Mechanisms of Control and Factors Driving Inflammation in HIV Controllers from a high incidence setting in South Africa-Prospects for HIV Cure

Host Organisation

Institution Country
University of the Witwatersrand South Africa

Current Organisation

University of the Witwatersrand

Current Job Title

Senior Researcher

Areas Of Specialisation

Human Immuno-deficiency Virus (HIV)

Publications

The DARC-null trait is associated with moderate modulation of NK cell profiles and unaltered cytolytic T cell profiles in black South Africans
Authors:
Kewreshini K. Naidoo , author
Manish Sagar , editor
Zesuliwe B. Shangase , author
Tabassum Rashid , author
Ayanda Ngubane , author
Nasreen Ismail , author
Thumbi Ndung’u , author
Christina F. Thobakgale , author
Date:
2020-11-19
Journal:
PLOS ONE
Content:
Identifiers:
DOI: 10.1371/journal.pone.0242448
Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants.
Authors:
Thobakgale CF , author
Ramduth D , author
Reddy S , author
Mkhwanazi N , author
de Pierres C , author
Moodley E , author
Mphatswe W , author
Blanckenberg N , author
Cengimbo A , author
Prendergast A , author
Tudor-Williams G , author
Goulder PJ , author
Date:
2007-09-01
Journal:
Journal of virology
Content:
Identifiers:
PMID: 17881456
PMC: PMC2169079
DOI: 10.1128/JVI.00624-07
Neutrophil counts in persons of African origin.
Authors:
Thobakgale CF , author
Ndung'u T , author
Date:
2014-01-01
Journal:
Current opinion in hematology
Content:
Identifiers:
PMID: 24257098
DOI: 10.1097/moh.0000000000000007
Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
Authors:
Kiepiela P , author
Leslie AJ , author
Honeyborne I , author
Ramduth D , author
Thobakgale C , author
Chetty S , author
Rathnavalu P , author
Moore C , author
Pfafferott KJ , author
Hilton L , author
Zimbwa P , author
Moore S , author
Allen T , author
Goulder PJ , author
Date:
2004-12-01
Journal:
Nature
Content:
Identifiers:
PMID: 15592417
DOI: 10.1038/nature03113
Interleukin 1-Beta (IL-1β) Production by Innate Cells Following TLR Stimulation Correlates With TB Recurrence in ART-Treated HIV-Infected Patients.
Authors:
Thobakgale C , author
Naidoo K , author
McKinnon LR , author
Werner L , author
Samsunder N , author
Karim SA , author
Ndungʼu T , author
Altfeld M , author
Naidoo K , author
Date:
2017-02-01
Journal:
Journal of acquired immune deficiency syndromes (1999)
Content:
Identifiers:
PMID: 27654812
PMC: PMC5237660
DOI: 10.1097/qai.0000000000001181
Impact of select immunologic and virologic biomarkers on CD4 cell count decrease in patients with chronic HIV-1 subtype C infection: results from Sinikithemba Cohort, Durban, South Africa.
Authors:
Brumme Z , author
Wang B , author
Nair K , author
Brumme C , author
de Pierres C , author
Reddy S , author
Julg B , author
Moodley E , author
Thobakgale C , author
Lu Z , author
van der Stok M , author
Bishop K , author
Mncube Z , author
Chonco F , author
Losina E , author
Date:
2009-09-01
Journal:
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Content:
Identifiers:
PMID: 19663693
PMC: PMC2777678
DOI: 10.1086/605503
Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection.
Authors:
Muenchhoff M , author
Adland E , author
Karimanzira O , author
Crowther C , author
Pace M , author
Csala A , author
Leitman E , author
Moonsamy A , author
McGregor C , author
Hurst J , author
Groll A , author
Mori M , author
Sinmyee S , author
Goulder P , author
Date:
2016-09-01
Journal:
Science translational medicine
Content:
Identifiers:
PMID: 27683550
PMC: PMC6087524
DOI: 10.1126/scitranslmed.aag1048
Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.
Authors:
Leslie A , author
Kavanagh D , author
Honeyborne I , author
Pfafferott K , author
Edwards C , author
Pillay T , author
Hilton L , author
Thobakgale C , author
Ramduth D , author
Draenert R , author
Le Gall S , author
Luzzi G , author
Edwards A , author
Goulder P , author
Date:
2005-03-01
Journal:
The Journal of experimental medicine
Content:
Identifiers:
PMID: 15781581
PMC: PMC2213090
DOI: 10.1084/jem.20041455
High frequency of rapid immunological progression in African infants infected in the era of perinatal HIV prophylaxis.
Authors:
Mphatswe W , author
Blanckenberg N , author
Tudor-Williams G , author
Prendergast A , author
Thobakgale C , author
Mkhwanazi N , author
McCarthy N , author
Walker BD , author
Kiepiela P , author
Goulder P , author
Date:
2007-06-01
Journal:
AIDS (London, England)
Content:
Identifiers:
PMID: 17545701
DOI: 10.1097/qad.0b013e3281a3bec2
KIR-HLA footprints and NK cell-mediated recognition of HIV-1.
Authors:
Thobakgale C , author
Carlson J , author
Wright J , author
van Teijlingen N , author
Jaggernath M , author
Goulder P , author
Walker B , author
Carrington M , author
Heckerman D , author
Altfeld M , author
Ndung'u T , author
Date:
2012-09-01
Journal:
Retrovirology
Content:
Identifiers:
PMC: PMC3441946
DOI: 10.1186/1742-4690-9-S2-P170
Frequent and strong antibody-mediated natural killer cell activation in response to HIV-1 Env in individuals with chronic HIV-1 infection.
Authors:
Thobakgale CF , author
Fadda L , author
Lane K , author
Toth I , author
Pereyra F , author
Bazner S , author
Ndung'u T , author
Walker BD , author
Rosenberg ES , author
Alter G , author
Carrington M , author
Allen TM , author
Altfeld M , author
Date:
2012-04-01
Journal:
Journal of virology
Content:
Identifiers:
PMID: 22496218
PMC: PMC3393568
DOI: 10.1128/JVI.00569-12
Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.
Authors:
Ngumbela KC , author
Day CL , author
Mncube Z , author
Nair K , author
Ramduth D , author
Thobakgale C , author
Moodley E , author
Reddy S , author
de Pierres C , author
Mkhwanazi N , author
Bishop K , author
van der Stok M , author
Ismail N , author
Walker BD , author
Date:
2008-01-01
Journal:
AIDS research and human retroviruses
Content:
Identifiers:
PMID: 18275350
DOI: 10.1089/aid.2007.0124
Impact of HLA in mother and child on disease progression of pediatric human immunodeficiency virus type 1 infection.
Authors:
Thobakgale CF , author
Prendergast A , author
Crawford H , author
Mkhwanazi N , author
Ramduth D , author
Reddy S , author
Molina C , author
Mncube Z , author
Leslie A , author
Prado J , author
Chonco F , author
Mphatshwe W , author
Goulder PJ , author
Date:
2009-07-01
Journal:
Journal of virology
Content:
Identifiers:
PMID: 19605475
PMC: PMC2748050
DOI: 10.1128/JVI.00921-09
Greentree white paper: sexual violence, genitoanal injury, and HIV: priorities for research, policy, and practice.
Authors:
Klot JF , author
Auerbach JD , author
Veronese F , author
Brown G , author
Pei A , author
Wira CR , author
Hope TJ , author
M'boup S , author
Greentree Meeting on Sexual Violence and HIV , author
Date:
2012-11-01
Journal:
AIDS research and human retroviruses
Content:
Identifiers:
PMID: 22953712
PMC: PMC3485903
DOI: 10.1089/aid.2012.0273
Early virological suppression with three-class antiretroviral therapy in HIV-infected African infants.
Authors:
Prendergast A , author
Mphatswe W , author
Tudor-Williams G , author
Rakgotho M , author
Pillay V , author
Thobakgale C , author
McCarthy N , author
Morris L , author
Walker BD , author
Goulder P , author
Date:
2008-07-01
Journal:
AIDS (London, England)
Content:
Identifiers:
PMID: 18580613
DOI: 10.1097/qad.0b013e32830437df
Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.
Authors:
Ramduth D , author
Day CL , author
Thobakgale CF , author
Mkhwanazi NP , author
de Pierres C , author
Reddy S , author
van der Stok M , author
Mncube Z , author
Nair K , author
Moodley ES , author
Kaufmann DE , author
Streeck H , author
Walker BD , author
Date:
2009-04-01
Journal:
PloS one
Content:
Identifiers:
PMID: 19352428
PMC: PMC2661367
DOI: 10.1371/journal.pone.0005013
Selection of an HLA-C*03:04-Restricted HIV-1 p24 Gag Sequence Variant Is Associated with Viral Escape from KIR2DL3+ Natural Killer Cells: Data from an Observational Cohort in South Africa.
Authors:
Hölzemer A , author
Thobakgale CF , author
Jimenez Cruz CA , author
Garcia-Beltran WF , author
Carlson JM , author
van Teijlingen NH , author
Mann JK , author
Jaggernath M , author
Kang SG , author
Körner C , author
Chung AW , author
Altfeld M , author
Date:
2015-11-01
Journal:
PLoS medicine
Content:
Identifiers:
PMID: 26575988
PMC: PMC4648589
DOI: 10.1371/journal.pmed.1001900
P07-07. Non-progressive paediatric HIV infection is associated with virus attenuation and increase in CD8+ specific T cell responses over time.
Authors:
Prado J , author
Prendergast A , author
Thobakgale C , author
Juarez C , author
Tudor-Williams A , author
Ndung'u T , author
Walker B , author
Goulder P , author
Date:
2009-10-01
Journal:
Retrovirology
Content:
Identifiers:
PMC: PMC2767588
DOI: 10.1186/1742-4690-6-S3-P105
Replicative capacity of human immunodeficiency virus type 1 transmitted from mother to child is associated with pediatric disease progression rate.
Authors:
Prado JG , author
Prendergast A , author
Thobakgale C , author
Molina C , author
Tudor-Williams G , author
Ndung'u T , author
Walker BD , author
Goulder P , author
Date:
2010-01-01
Journal:
Journal of virology
Content:
Identifiers:
PMID: 19828603
PMC: PMC2798410
DOI: 10.1128/JVI.01743-09
Detection of HIV type 1 gag-specific CD4(+) T cell responses in acutely infected infants.
Authors:
Ramduth D , author
Thobakgale CF , author
Mkhwanazi NP , author
De Pierres C , author
Reddy S , author
van der Stok M , author
Mncube Z , author
Mphatswe W , author
Blanckenberg N , author
Cengimbo A , author
Prendergast A , author
Walker BD , author
Date:
2008-02-01
Journal:
AIDS research and human retroviruses
Content:
Identifiers:
PMID: 18284325
DOI: 10.1089/aid.2007.0096
Raising antibodies in chickens against primaquine, pyrimethamine, dapsone, tetracycline, and doxycycline.
Authors:
Goldring JP , author
Thobakgale C , author
Hiltunen T , author
Coetzer TH , author
Date:
2005-01-01
Journal:
Immunological investigations
Content:
Identifiers:
PMID: 15773575
DOI: 10.1081/imm-200049537
Reduced Expression of Siglec-7, NKG2A, and CD57 on Terminally Differentiated CD56-CD16+ Natural Killer Cell Subset Is Associated with Natural Killer Cell Dysfunction in Chronic HIV-1 Clade C Infection.
Authors:
Zulu MZ , author
Naidoo KK , author
Mncube Z , author
Jaggernath M , author
Goulder PJR , author
Ndung'u T , author
Altfeld M , author
Thobakgale CF , author
Date:
2017-09-01
Journal:
AIDS research and human retroviruses
Content:
Identifiers:
PMID: 28810810
DOI: 10.1089/aid.2017.0095
Immunodominant HIV-1-specific HLA-B- and HLA-C-restricted CD8+ T cells do not differ in polyfunctionality.
Authors:
Mkhwanazi N , author
Thobakgale CF , author
van der Stok M , author
Reddy S , author
Mncube Z , author
Chonco F , author
Walker BD , author
Altfeld M , author
Goulder PJ , author
Ndung'u T , author
Date:
2010-07-01
Journal:
Virology
Content:
Identifiers:
PMID: 20638093
PMC: PMC2954365
DOI: 10.1016/j.virol.2010.06.002
CD8+ T Cell Breadth and Ex Vivo Virus Inhibition Capacity Distinguish between Viremic Controllers with and without Protective HLA Class I Alleles.
Authors:
Koofhethile CK , author
Ndhlovu ZM , author
Thobakgale-Tshabalala C , author
Prado JG , author
Ismail N , author
Mncube Z , author
Mkhize L , author
van der Stok M , author
Yende N , author
Walker BD , author
Goulder PJR , author
Ndung'u T , author
Date:
2016-07-01
Journal:
Journal of virology
Content:
Identifiers:
PMID: 27194762
PMC: PMC4944274
DOI: 10.1128/JVI.00276-16
Role of HIV-specific CD8+ T cells in pediatric HIV cure strategies after widespread early viral escape.
Authors:
Leitman EM , author
Thobakgale CF , author
Adland E , author
Ansari MA , author
Raghwani J , author
Prendergast AJ , author
Tudor-Williams G , author
Kiepiela P , author
Hemelaar J , author
Brener J , author
Tsai MH , author
Mori M , author
Goulder PJR , author
Date:
2017-10-01
Journal:
The Journal of experimental medicine
Content:
Identifiers:
PMID: 28983013
PMC: PMC5679167
DOI: 10.1084/jem.20162123
Frequent and strong antibody-mediated NK cell activation to HIV-1 Env in individuals with chronic HIV-1 infection.
Authors:
Thobakgale C , author
Fadda L , author
Lane K , author
Toth I , author
Pereyra F , author
Bazner S , author
Ndung'u T , author
Walker B , author
Rosenberg E , author
Alter G , author
Carrington M , author
Allen T , author
Altfeld M , author
Date:
2012-09-01
Journal:
Retrovirology
Content:
Identifiers:
PMC: PMC3441410
DOI: 10.1186/1742-4690-9-S2-P171
Short communication: CD8(+) T cell polyfunctionality profiles in progressive and nonprogressive pediatric HIV type 1 infection.
Authors:
Thobakgale CF , author
Streeck H , author
Mkhwanazi N , author
Mncube Z , author
Maphumulo L , author
Chonco F , author
Prendergast A , author
Tudor-Williams G , author
Walker BD , author
Goulder PJ , author
Altfeld M , author
Ndung'u T , author
Date:
2011-03-01
Journal:
AIDS research and human retroviruses
Content:
Identifiers:
PMID: 21288139
PMC: PMC3332389
DOI: 10.1089/aid.2010.0227
Mother-to-Child HIV Transmission Bottleneck Selects for Consensus Virus with Lower Gag-Protease-Driven Replication Capacity.
Authors:
Naidoo VL , author
Mann JK , author
Noble C , author
Adland E , author
Carlson JM , author
Thomas J , author
Brumme CJ , author
Thobakgale-Tshabalala CF , author
Brumme ZL , author
Brockman MA , author
Goulder PJR , author
Ndung'u T , author
Date:
2017-08-01
Journal:
Journal of virology
Content:
Identifiers:
PMID: 28637761
PMC: PMC5553170
DOI: 10.1128/jvi.00518-17
Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection.
Authors:
Adland E , author
Paioni P , author
Thobakgale C , author
Laker L , author
Mori L , author
Muenchhoff M , author
Csala A , author
Clapson M , author
Flynn J , author
Novelli V , author
Hurst J , author
Naidoo V , author
Shapiro R , author
Huang KH , author
Goulder PJ , author
Date:
2015-06-01
Journal:
PLoS pathogens
Content:
Identifiers:
PMID: 26076345
PMC: PMC4468173
DOI: 10.1371/journal.ppat.1004954
P07-02. Cytotoxic T lymphocyte-mediated immune responses in HIV-1 clade C infected mother-child pairs.
Authors:
Moodley E , author
Thobakgale C , author
Ramkalawon P , author
Vanderstok M , author
Mncube Z , author
Bishop K , author
Reddy S , author
Chonco F , author
Walker B , author
Goulder P , author
Ndung'u T , author
Date:
2009-10-01
Journal:
Retrovirology
Content:
Identifiers:
PMC: PMC2767583
DOI: 10.1186/1742-4690-6-s3-p100
Fitness cost of escape mutations in p24 Gag in association with control of human immunodeficiency virus type 1.
Authors:
Martinez-Picado J , author
Prado JG , author
Fry EE , author
Pfafferott K , author
Leslie A , author
Chetty S , author
Thobakgale C , author
Honeyborne I , author
Crawford H , author
Matthews P , author
Pillay T , author
Rousseau C , author
Goulder P , author
Date:
2006-04-01
Journal:
Journal of virology
Content:
Identifiers:
PMID: 16537629
PMC: PMC1440414
DOI: 10.1128/JVI.80.7.3617-3623.2006
Correction for Thobakgale et al., Impact of HLA in Mother and Child on Disease Progression of Pediatric Human Immunodeficiency Virus Type 1 Infection.
Authors:
Thobakgale CF , author
Prendergast A , author
Crawford H , author
Mkhwanazi N , author
Ramduth D , author
Reddy S , author
Molina C , author
Mncube Z , author
Leslie A , author
Prado J , author
Chonco F , author
Mphatshwe W , author
Goulder PJ , author
Date:
2015-07-01
Journal:
Journal of virology
Content:
Identifiers:
PMID: 26157156
PMC: PMC4505637
DOI: 10.1128/JVI.00876-15
Oral abstracts of the 21st International AIDS Conference 18-22 July 2016, Durban, South Africa.
Authors:
Date:
2016-07-01
Journal:
Journal of the International AIDS Society
Content:
Identifiers:
PMID: 27460772
PMC: PMC4960637
DOI: 10.7448/IAS.19.6.21264
CD8+ T-cell responses to different HIV proteins have discordant associations with viral load.
Authors:
Kiepiela P , author
Ngumbela K , author
Thobakgale C , author
Ramduth D , author
Honeyborne I , author
Moodley E , author
Reddy S , author
de Pierres C , author
Mncube Z , author
Mkhwanazi N , author
Bishop K , author
van der Stok M , author
Goulder P , author
Date:
2006-12-01
Journal:
Nature medicine
Content:
Identifiers:
PMID: 17173051
DOI: 10.1038/nm1520

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