|Call||EDCTP-AREF Preparatory Fellowships (PF)|
Developing advanced Genomics and Bioinformatics skills and application to uncover route of transmission of Buruli ulcer in Africa.
The fellowship primarily aimed to build capacity in advanced Genomics and Bioinformatics with application to Buruli ulcer disease.
|Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana||Ghana|
|University of Yaounde 1||Cameroon|
|Prof. Jude Bigoga||The Biotechnology Centre, University of Yaounde 1||Cameroon|
|Prof. Anthony Ablordey||Noguchi Memorial Institute for Medical Research, College of Health Science, University of Ghana||Ghana|
 Capacity building in advanced Genomics technologies.  Capacity building in advanced Bioinformatics.  Population genomics study of M. ulcerans isolates from Buruli ulcer endemic areas in Cameroon.  Deepen research partnerships and develop new networking.
|Title||University||Start Date||End Date|
|Ph.D in Biochemistry [thesis in Molecular Epidemiology of Infectious Diseases]||University of Yaounde 1, Cameroon||2013-02-04||2018-12-10|
|Zeukeng F, Anthony A, Kakou-Ngazoa ES, Ghogomu MS, Coulibaly ND, Ngo-Nsonga MT, Mbacham FW, Bigoga DJ, Djouaka R. Community-based geographical distribution of Mycobacterium ulcerans VNTR-genotypes from the environment and humans in the Nyong valley, Cameroon. Trop Med Health. 2021, 49:41. https://doi.org/10.1186/s41182-021-00330-2 .|
The Biotechnology Centre, University of Yaounde 1, Cameroon
|Role||Committee/board||Start Date||End Date|
|Member||International Society for Neglected Tropical Diseases (ISNTD)||2021||2022|
Tuberculosis (TB) Malaria Neglected Infectious Diseases (NID)
Malaria remains one of the main causes of morbidity and mortality in Cameroon. To inform vector control intervention decision making, malaria vector surveillance was conducted monthly from October 2018 to September 2020 in five selected sentinel sites (Gounougou and Simatou in the North, and Bonabéri, Mangoum and Nyabessang in the South).
Human landing catches (HLCs), U.S. Centers for Disease Control and Prevention (CDC) light traps, and pyrethrum spray catches (PSCs) were used to assess vector density, species composition, human biting rate (HBR), endophagic index, indoor resting density (IRD), parity, sporozoite infection rates, entomological inoculation rate (EIR), and
A total of 139,322
These findings highlight the high malaria transmission occurring in Cameroon and will support the National Malaria Control Program to design evidence-based malaria vector control strategies, and deployment of effective and integrated vector control interventions to reduce malaria transmission and burden in Cameroon, where several
Insecticide-based vector control is responsible for reducing malaria mortality and morbidity. Its success depends on a better knowledge of the vector, its distribution, and resistance status to the insecticides used. In this paper, we assessed Anopheles gambiae sensu lato (A gambiae s.l.) population resistance to pyrethroids in different ecological settings.
The World Health Organization standard bioassay test was used to assess F0A gambiae s.l. susceptibility to pyrethroids. Biochemical Synergist assays were conducted with piperonyl butoxide (PBO), S,S,S-tributyl phosphotritioate, and diethyl maleate. L1014F, L1014S, and N1575Y knockdown resistance (kdr) mutations were investigated using TaqMan genotyping.
Anopheles gambiae sensu lato was composed of Anopheles arabienisis, Anopheles coluzzii, and A gambiae in all study sites. Anopheles gambiae sensu lato showed a strong phenotypic resistance to deltamethrin and permethrin in all sites (13% to 41% mortality). In many sites, pre-exposure to synergists partially improved the mortality rate suggesting the presence of detoxifying enzymes. The 3 kdr (L1014F, L1014S, and N1575Y) mutations were found, with a predominance of L1014F, in all species.
Multiple resistance mechanisms to pyrethroids were observed in A gambiae s.l. in Mali. The PBO provided a better partial restoration of susceptibility to pyrethroids, suggesting that the efficacy of long-lasting insecticidal nets may be improved with PBO.
Cameroon is considering the implementation of indoor residual spraying (IRS) as a complementary measure to control malaria in the context of high pyrethroid resistance in major malaria vectors. Non-pyrethroid insecticide classes such as organophosphates and carbamates may be utilized in IRS due to widespread pyrethroid resistance. However, the success of this strategy depends on good knowledge of the resistance status of malaria vectors to carbamates and organophosphates. Here, we assessed the susceptibility profile of
Pirimiphos-methyl induced full mortality in
The occurrence of the
Malaria remains endemic in Cameroon, with heterogeneous transmission related to eco-climatic variations, vector diversity and spatial distribution. The intensification of malaria prevention and control through the free distribution of insecticide-treated nets in recent years may have altered the composition, geographic distribution and natural infection rate of
Mosquitoes were sampled (indoors and outdoors) in 11 eco-epidemiological settings at low (18–197 m), intermediate (371–584 m) and high (740–1067 m) altitude by nightly human landing catches. The mosquitoes were identified morphologically and
A total of 7327 (18.0 mosquitoes/trap/night) mosquitoes were trapped, mainly during the rainy season (5678, 77.5%) and at low altitude (3669, 50.1%).
The long-lasting insecticidal nets (LLINs) and indoor residual spraying of insecticide (IRS) are major malaria vector control strategies in Mali. The success of control strategies depends on a better understanding of the status of malaria vectors with respect to the insecticides used. In this study we evaluate the level of resistance of
The three species of the
The study highlights the implication of G119S mutation in bendiocarb resistance in